Palmitic acid induces autophagy in hepatocytes via JNK2 activation

Aim： Free fatty acid-induced lipotoxicity plays a crucial role in the progression of nonalcoholic fatty liver disease （NAFLD）. In the present study we investigated the effects of a high-fat diet and free fatty acids on the autophagic process in hepatocytes in vivo and in vitro and the underlying mec...

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Veröffentlicht in:	Acta pharmacologica Sinica 2014-04, Vol.35 (4), p.504-512
Hauptverfasser:	Tu, Qian-qian, Zheng, Rui-ying, Li, Juan, Hu, Liang, Chang, Yan-xin, Li, Liang, Li, Min-hong, Wang, Ruo-yu, Huang, Dan-dan, Wu, Meng-chao, Hu, He-ping, Chen, Lei, Wang, Hong-yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Autophagy - drug effects Autophagy-Related Protein 5 Beclin-1 Biomedical and Life Sciences Biomedicine Diet, High-Fat Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Hep G2 Cells Hepatocytes - drug effects Hepatocytes - enzymology Hepatocytes - pathology HepG2细胞 Humans Immunology Internal Medicine Medical Microbiology Membrane Proteins - genetics Membrane Proteins - metabolism Mice, Inbred C57BL Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitogen-Activated Protein Kinase 8 - genetics Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology Original original-article Palmitic Acid - toxicity Pharmacology/Toxicology Protein Kinase Inhibitors - pharmacology RNA Interference Signal Transduction - drug effects SMMC-7721细胞 Time Factors Transfection Vaccine 棕榈酸游离脂肪酸肝细胞自噬作用诱导高脂肪饮食
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