Particle tracking in drug and gene delivery research: State-of-the-art applications and methods

Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Advanced drug delivery reviews 2015-08, Vol.91, p.70-91
Hauptverfasser: Schuster, Benjamin S., Ensign, Laura M., Allan, Daniel B., Suk, Jung Soo, Hanes, Justin
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 91
container_issue
container_start_page 70
container_title Advanced drug delivery reviews
container_volume 91
creator Schuster, Benjamin S.
Ensign, Laura M.
Allan, Daniel B.
Suk, Jung Soo
Hanes, Justin
description Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful. [Display omitted]
doi_str_mv 10.1016/j.addr.2015.03.017
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4813524</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169409X15000563</els_id><sourcerecordid>1710983914</sourcerecordid><originalsourceid>FETCH-LOGICAL-c591t-8a415f87762fa3662bf691f76c5fce46c957c289409843381dbc068f863c19e43</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhYnROO3oC7gwLN1UyU8VBcaYmIl_ySSaqIk7QsOlm7YaWqA7mbeXsseJblyx4Dvf5XIQekpJTwkVL3a9cS73jNCxJ7wndLqHVlROrJNMDffRqkGqG4j6foEelbIjhLJJkIfogo1ylEIMK6Q_m1yDnQHXbOyPEDc4ROzycYNNdHgDEbCDOZwg3-AMBUy225f4SzUVuuS7uoWuGbA5HOZgTQ0plt_JPdRtcuUxeuDNXODJ7XmJvr17-_XqQ3f96f3HqzfXnR0VrZ00Ax29nCbBvOFCsLUXivpJ2NFbGIRV42SZVG0ZOXAuqVtbIqSXgluqYOCX6PXZeziu9-AsxLbPrA857E2-0ckE_e9NDFu9SSc9SMpHtgie3wpy-nmEUvU-FAvzbCKkY9F0om02V3RB2Rm1OZWSwd-NoUQvzeidXprRSzOacN2aaaFnfz_wLvKniga8OgPQvukUIOtiA0QLLmSwVbsU_uf_BQhkoKM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1710983914</pqid></control><display><type>article</type><title>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Schuster, Benjamin S. ; Ensign, Laura M. ; Allan, Daniel B. ; Suk, Jung Soo ; Hanes, Justin</creator><creatorcontrib>Schuster, Benjamin S. ; Ensign, Laura M. ; Allan, Daniel B. ; Suk, Jung Soo ; Hanes, Justin</creatorcontrib><description>Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful. [Display omitted]</description><identifier>ISSN: 0169-409X</identifier><identifier>EISSN: 1872-8294</identifier><identifier>DOI: 10.1016/j.addr.2015.03.017</identifier><identifier>PMID: 25858664</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Algorithms ; Animals ; Automated particle tracking ; Biological barrier ; Diffusion ; Drug Delivery Systems ; Gene Transfer Techniques ; Genetic Therapy - methods ; Humans ; Image analysis ; Microscopy ; Microscopy - methods ; Mucus ; Nanomedicine ; Nanomedicine - methods ; Nanoparticle ; Nanoparticles</subject><ispartof>Advanced drug delivery reviews, 2015-08, Vol.91, p.70-91</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-8a415f87762fa3662bf691f76c5fce46c957c289409843381dbc068f863c19e43</citedby><cites>FETCH-LOGICAL-c591t-8a415f87762fa3662bf691f76c5fce46c957c289409843381dbc068f863c19e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0169409X15000563$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25858664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schuster, Benjamin S.</creatorcontrib><creatorcontrib>Ensign, Laura M.</creatorcontrib><creatorcontrib>Allan, Daniel B.</creatorcontrib><creatorcontrib>Suk, Jung Soo</creatorcontrib><creatorcontrib>Hanes, Justin</creatorcontrib><title>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</title><title>Advanced drug delivery reviews</title><addtitle>Adv Drug Deliv Rev</addtitle><description>Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful. [Display omitted]</description><subject>Algorithms</subject><subject>Animals</subject><subject>Automated particle tracking</subject><subject>Biological barrier</subject><subject>Diffusion</subject><subject>Drug Delivery Systems</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Therapy - methods</subject><subject>Humans</subject><subject>Image analysis</subject><subject>Microscopy</subject><subject>Microscopy - methods</subject><subject>Mucus</subject><subject>Nanomedicine</subject><subject>Nanomedicine - methods</subject><subject>Nanoparticle</subject><subject>Nanoparticles</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEUhYnROO3oC7gwLN1UyU8VBcaYmIl_ySSaqIk7QsOlm7YaWqA7mbeXsseJblyx4Dvf5XIQekpJTwkVL3a9cS73jNCxJ7wndLqHVlROrJNMDffRqkGqG4j6foEelbIjhLJJkIfogo1ylEIMK6Q_m1yDnQHXbOyPEDc4ROzycYNNdHgDEbCDOZwg3-AMBUy225f4SzUVuuS7uoWuGbA5HOZgTQ0plt_JPdRtcuUxeuDNXODJ7XmJvr17-_XqQ3f96f3HqzfXnR0VrZ00Ax29nCbBvOFCsLUXivpJ2NFbGIRV42SZVG0ZOXAuqVtbIqSXgluqYOCX6PXZeziu9-AsxLbPrA857E2-0ckE_e9NDFu9SSc9SMpHtgie3wpy-nmEUvU-FAvzbCKkY9F0om02V3RB2Rm1OZWSwd-NoUQvzeidXprRSzOacN2aaaFnfz_wLvKniga8OgPQvukUIOtiA0QLLmSwVbsU_uf_BQhkoKM</recordid><startdate>20150830</startdate><enddate>20150830</enddate><creator>Schuster, Benjamin S.</creator><creator>Ensign, Laura M.</creator><creator>Allan, Daniel B.</creator><creator>Suk, Jung Soo</creator><creator>Hanes, Justin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150830</creationdate><title>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</title><author>Schuster, Benjamin S. ; Ensign, Laura M. ; Allan, Daniel B. ; Suk, Jung Soo ; Hanes, Justin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-8a415f87762fa3662bf691f76c5fce46c957c289409843381dbc068f863c19e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Automated particle tracking</topic><topic>Biological barrier</topic><topic>Diffusion</topic><topic>Drug Delivery Systems</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Therapy - methods</topic><topic>Humans</topic><topic>Image analysis</topic><topic>Microscopy</topic><topic>Microscopy - methods</topic><topic>Mucus</topic><topic>Nanomedicine</topic><topic>Nanomedicine - methods</topic><topic>Nanoparticle</topic><topic>Nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuster, Benjamin S.</creatorcontrib><creatorcontrib>Ensign, Laura M.</creatorcontrib><creatorcontrib>Allan, Daniel B.</creatorcontrib><creatorcontrib>Suk, Jung Soo</creatorcontrib><creatorcontrib>Hanes, Justin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuster, Benjamin S.</au><au>Ensign, Laura M.</au><au>Allan, Daniel B.</au><au>Suk, Jung Soo</au><au>Hanes, Justin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-08-30</date><risdate>2015</risdate><volume>91</volume><spage>70</spage><epage>91</epage><pages>70-91</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful. [Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25858664</pmid><doi>10.1016/j.addr.2015.03.017</doi><tpages>22</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0169-409X
ispartof Advanced drug delivery reviews, 2015-08, Vol.91, p.70-91
issn 0169-409X
1872-8294
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4813524
source MEDLINE; Elsevier ScienceDirect Journals
subjects Algorithms
Animals
Automated particle tracking
Biological barrier
Diffusion
Drug Delivery Systems
Gene Transfer Techniques
Genetic Therapy - methods
Humans
Image analysis
Microscopy
Microscopy - methods
Mucus
Nanomedicine
Nanomedicine - methods
Nanoparticle
Nanoparticles
title Particle tracking in drug and gene delivery research: State-of-the-art applications and methods
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T16%3A42%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Particle%20tracking%20in%20drug%20and%20gene%20delivery%20research:%20State-of-the-art%20applications%20and%20methods&rft.jtitle=Advanced%20drug%20delivery%20reviews&rft.au=Schuster,%20Benjamin%20S.&rft.date=2015-08-30&rft.volume=91&rft.spage=70&rft.epage=91&rft.pages=70-91&rft.issn=0169-409X&rft.eissn=1872-8294&rft_id=info:doi/10.1016/j.addr.2015.03.017&rft_dat=%3Cproquest_pubme%3E1710983914%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1710983914&rft_id=info:pmid/25858664&rft_els_id=S0169409X15000563&rfr_iscdi=true