Particle tracking in drug and gene delivery research: State-of-the-art applications and methods
Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during th...
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Veröffentlicht in: | Advanced drug delivery reviews 2015-08, Vol.91, p.70-91 |
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creator | Schuster, Benjamin S. Ensign, Laura M. Allan, Daniel B. Suk, Jung Soo Hanes, Justin |
description | Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful.
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doi_str_mv | 10.1016/j.addr.2015.03.017 |
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[Display omitted]</description><subject>Algorithms</subject><subject>Animals</subject><subject>Automated particle tracking</subject><subject>Biological barrier</subject><subject>Diffusion</subject><subject>Drug Delivery Systems</subject><subject>Gene Transfer Techniques</subject><subject>Genetic Therapy - methods</subject><subject>Humans</subject><subject>Image analysis</subject><subject>Microscopy</subject><subject>Microscopy - methods</subject><subject>Mucus</subject><subject>Nanomedicine</subject><subject>Nanomedicine - methods</subject><subject>Nanoparticle</subject><subject>Nanoparticles</subject><issn>0169-409X</issn><issn>1872-8294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2OFCEUhYnROO3oC7gwLN1UyU8VBcaYmIl_ySSaqIk7QsOlm7YaWqA7mbeXsseJblyx4Dvf5XIQekpJTwkVL3a9cS73jNCxJ7wndLqHVlROrJNMDffRqkGqG4j6foEelbIjhLJJkIfogo1ylEIMK6Q_m1yDnQHXbOyPEDc4ROzycYNNdHgDEbCDOZwg3-AMBUy225f4SzUVuuS7uoWuGbA5HOZgTQ0plt_JPdRtcuUxeuDNXODJ7XmJvr17-_XqQ3f96f3HqzfXnR0VrZ00Ax29nCbBvOFCsLUXivpJ2NFbGIRV42SZVG0ZOXAuqVtbIqSXgluqYOCX6PXZeziu9-AsxLbPrA857E2-0ckE_e9NDFu9SSc9SMpHtgie3wpy-nmEUvU-FAvzbCKkY9F0om02V3RB2Rm1OZWSwd-NoUQvzeidXprRSzOacN2aaaFnfz_wLvKniga8OgPQvukUIOtiA0QLLmSwVbsU_uf_BQhkoKM</recordid><startdate>20150830</startdate><enddate>20150830</enddate><creator>Schuster, Benjamin S.</creator><creator>Ensign, Laura M.</creator><creator>Allan, Daniel B.</creator><creator>Suk, Jung Soo</creator><creator>Hanes, Justin</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150830</creationdate><title>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</title><author>Schuster, Benjamin S. ; Ensign, Laura M. ; Allan, Daniel B. ; Suk, Jung Soo ; Hanes, Justin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-8a415f87762fa3662bf691f76c5fce46c957c289409843381dbc068f863c19e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Automated particle tracking</topic><topic>Biological barrier</topic><topic>Diffusion</topic><topic>Drug Delivery Systems</topic><topic>Gene Transfer Techniques</topic><topic>Genetic Therapy - methods</topic><topic>Humans</topic><topic>Image analysis</topic><topic>Microscopy</topic><topic>Microscopy - methods</topic><topic>Mucus</topic><topic>Nanomedicine</topic><topic>Nanomedicine - methods</topic><topic>Nanoparticle</topic><topic>Nanoparticles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuster, Benjamin S.</creatorcontrib><creatorcontrib>Ensign, Laura M.</creatorcontrib><creatorcontrib>Allan, Daniel B.</creatorcontrib><creatorcontrib>Suk, Jung Soo</creatorcontrib><creatorcontrib>Hanes, Justin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Advanced drug delivery reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuster, Benjamin S.</au><au>Ensign, Laura M.</au><au>Allan, Daniel B.</au><au>Suk, Jung Soo</au><au>Hanes, Justin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Particle tracking in drug and gene delivery research: State-of-the-art applications and methods</atitle><jtitle>Advanced drug delivery reviews</jtitle><addtitle>Adv Drug Deliv Rev</addtitle><date>2015-08-30</date><risdate>2015</risdate><volume>91</volume><spage>70</spage><epage>91</epage><pages>70-91</pages><issn>0169-409X</issn><eissn>1872-8294</eissn><abstract>Particle tracking is a powerful microscopy technique to quantify the motion of individual particles at high spatial and temporal resolution in complex fluids and biological specimens. Particle tracking's applications and impact in drug and gene delivery research have greatly increased during the last decade. Thanks to advances in hardware and software, this technique is now more accessible than ever, and can be reliably automated to enable rapid processing of large data sets, thereby further enhancing the role that particle tracking will play in drug and gene delivery studies in the future. We begin this review by discussing particle tracking-based advances in characterizing extracellular and cellular barriers to therapeutic nanoparticles and in characterizing nanoparticle size and stability. To facilitate wider adoption of the technique, we then present a user-friendly review of state-of-the-art automated particle tracking algorithms and methods of analysis. We conclude by reviewing technological developments for next-generation particle tracking methods, and we survey future research directions in drug and gene delivery where particle tracking may be useful.
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subjects | Algorithms Animals Automated particle tracking Biological barrier Diffusion Drug Delivery Systems Gene Transfer Techniques Genetic Therapy - methods Humans Image analysis Microscopy Microscopy - methods Mucus Nanomedicine Nanomedicine - methods Nanoparticle Nanoparticles |
title | Particle tracking in drug and gene delivery research: State-of-the-art applications and methods |
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