Adenosine A1 receptor activation attenuates cardiac hypertrophy and fibrosis in response to α1‐adrenoceptor stimulation in vivo

Background and Purpose Adenosine has been proposed to exert anti‐hypertrophic effects. However, the precise regulation and the role of the different adenosine receptor subtypes in the heart and their effects on hypertrophic signalling are largely unknown. We aimed to characterize expression and func...

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Veröffentlicht in:	British journal of pharmacology 2016-01, Vol.173 (1), p.88-102
Hauptverfasser:	Puhl, S‐L, Kazakov, A, Müller, A, Fries, P, Wagner, D R, Böhm, M, Maack, C, Devaux, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A1 Receptor Agonists - pharmacology Adrenergic alpha-1 Receptor Agonists - adverse effects Angiotensin II - pharmacology Animals Animals, Newborn Cardiomegaly - prevention & control Cell Culture Techniques Dose-Response Relationship, Drug Fibrosis - prevention & control Insulin-Like Growth Factor I - pharmacology Male Matrix Metalloproteinase 2 - metabolism Mice Myocytes, Cardiac - metabolism Oxidative Stress - drug effects Phenylephrine - antagonists & inhibitors Phenylephrine - pharmacology Rats Receptor, Adenosine A1 - metabolism Research Paper Research Papers Up-Regulation - drug effects
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