Characterization of 12 GnRH peptide agonists – a kinetic perspective

Background and Purpose Drug‐target residence time is an important, yet often overlooked, parameter in drug discovery. Multiple studies have proposed an increased residence time to be beneficial for improved drug efficacy and/or longer duration of action. Currently, there are many drugs on the market...

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Veröffentlicht in:	British journal of pharmacology 2016-01, Vol.173 (1), p.128-141
Hauptverfasser:	Nederpelt, Indira, Georgi, Victoria, Schiele, Felix, Nowak‐Reppel, Katrin, Fernández‐Montalván, Amaury E., IJzerman, Adriaan P., Heitman, Laura H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - drug effects CHO Cells Competition Cricetulus Fluorescent Dyes - pharmacology Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - analogs & derivatives Humans Iodine Radioisotopes Kinetics Peptides Pharmaceutical industry R&D Radioligand Assay - methods Receptors, LHRH - agonists Research & development Research Paper Research Papers Triptorelin Pamoate - pharmacology
Online-Zugang:	Volltext
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