Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

BACKGROUND AND PURPOSE—Pentraxin 3 (PTX3) is released on inflammatory responses in many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked whether and how PTX3 contributes to blood–brain barrier dysfunction during the acute phase of ischemic stroke. METHODS—In vivo, spon...

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Veröffentlicht in:	Stroke (1970) 2016-04, Vol.47 (4), p.1094-1100
Hauptverfasser:	Shindo, Akihiro, Maki, Takakuni, Mandeville, Emiri T, Liang, Anna C, Egawa, Naohiro, Itoh, Kanako, Itoh, Naoki, Borlongan, Mia, Holder, Julie C, Chuang, Tsu Tshen, McNeish, John D, Tomimoto, Hidekazu, Lok, Josephine, Lo, Eng H, Arai, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain - metabolism Brain - pathology C-Reactive Protein - metabolism Cell Death Culture Media, Conditioned Endothelial Cells - metabolism Endothelium, Vascular - metabolism Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Male Rats Rats, Inbred SHR Serum Amyloid P-Component - metabolism Stroke - metabolism Stroke - pathology Vascular Endothelial Growth Factor A - metabolism
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