Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

Nicotinamide adenine dinucleotide (NAD) is a cofactor in redox reactions and a substrate for NAD-consuming enzymes, such as PARPs and sirtuins. As cancer cells have increased NAD requirements, the main NAD salvage enzymes in humans, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinate phosp...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (2), p.1973-1983
Hauptverfasser:	Duarte-Pereira, Sara, Pereira-Castro, Isabel, Silva, Sarah S, Correia, Mariana Gonçalves, Neto, Célia, da Costa, Luís Teixeira, Amorim, António, Silva, Raquel M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Cytokines - genetics DNA Methylation Gene Expression Regulation, Neoplastic Humans Mutation - genetics Neoplasms - genetics Neoplasms - pathology Nicotinamide Phosphoribosyltransferase - genetics Pentosyltransferases - genetics Real-Time Polymerase Chain Reaction Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Tumor Cells, Cultured
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