Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

Here, we report a novel non-epigenetic function of histone deacetylase (HDAC) 8 in activating cancer stem cell (CSC)-like properties in breast cancer cells by enhancing the stability of Notch1 protein. The pan-HDAC inhibitors AR-42 and SAHA, and the class I HDAC inhibitor depsipeptide, suppressed ma...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (2), p.1796-1807
Hauptverfasser:	Chao, Min-Wu, Chu, Po-Chen, Chuang, Hsiao-Ching, Shen, Fang-Hsiu, Chou, Chih-Chien, Hsu, En-Chi, Himmel, Lauren E, Huang, Han-Li, Tu, Huang-Ju, Kulp, Samuel K, Teng, Che-Ming, Chen, Ching-Shih
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Depsipeptides - pharmacology Epigenesis, Genetic Female Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans MCF-7 Cells Mice, Inbred NOD Mice, SCID Microscopy, Confocal Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Nylons - pharmacology Phenylbutyrates - pharmacology Protein Stability Pyrroles - pharmacology Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Repressor Proteins - antagonists & inhibitors Repressor Proteins - genetics Repressor Proteins - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA Interference Spheroids, Cellular - drug effects Spheroids, Cellular - metabolism Transplantation, Heterologous
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