Multiplatform molecular profiling identifies potentially targetable biomarkers in malignant phyllodes tumors of the breast

Malignant phyllodes tumor is a rare breast malignancy with sarcomatous overgrowth and with limited effective treatment options for recurrent and metastatic cases. Recent clinical trials indicated a potential for anti-angiogenic, anti-EGFR and immunotherapeutic approaches for patients with sarcomas,...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (2), p.1707-1716
Hauptverfasser:	Gatalica, Zoran, Vranic, Semir, Ghazalpour, Anatole, Xiu, Joanne, Ocal, Idris Tolgay, McGill, John, Bender, Ryan P, Discianno, Erin, Schlum, Aaron, Sanati, Souzan, Palazzo, Juan, Reddy, Sandeep, Pockaj, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast Neoplasms - blood supply Breast Neoplasms - genetics Breast Neoplasms - metabolism Female Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Middle Aged Mutation Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oligonucleotide Array Sequence Analysis Phyllodes Tumor - blood supply Phyllodes Tumor - genetics Phyllodes Tumor - metabolism Receptor, Epidermal Growth Factor - genetics Research Paper Sequence Analysis, DNA - methods Young Adult
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