Infiltrating mast cells increase prostate cancer chemotherapy and radiotherapy resistances via modulation of p38/p53/p21 and ATM signals

Early studies indicated that mast cells in prostate tumor microenvironment might influence prostate cancer (PCa) progression. Their impacts to PCa therapy, however, remained unclear. Here we found PCa could recruit more mast cells than normal prostate epithelial cells then alter PCa chemotherapy and...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (2), p.1341-1353
Hauptverfasser:	Xie, Hongjun, Li, Chong, Dang, Qiang, Chang, Luke S, Li, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Ataxia Telangiectasia Mutated Proteins - metabolism Cell Line, Tumor Cell Movement Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Docetaxel Dose-Response Relationship, Drug Drug Resistance, Neoplasm Enzyme Activation Gene Expression Regulation, Neoplastic Humans Male Mast Cells - drug effects Mast Cells - enzymology Mast Cells - radiation effects Mice, Nude p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Radiation Tolerance Research Paper RNA Interference Signal Transduction - drug effects Signal Transduction - radiation effects Taxoids - pharmacology Time Factors Transfection Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
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