Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease
In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "tel...
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| Veröffentlicht in: | Pediatrics (Evanston) 2016-04, Vol.137 (4), p.1-1 |
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| creator | Factor-Litvak, Pam Susser, Ezra Kezios, Katrina McKeague, Ian Kark, Jeremy D Hoffman, Matthew Kimura, Masayuki Wapner, Ronald Aviv, Abraham |
| description | In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock," whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns.
LTL was measured in blood samples from 490 newborns and their parents.
LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086).
The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults. |
| doi_str_mv | 10.1542/peds.2015-3927 |
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LTL was measured in blood samples from 490 newborns and their parents.
LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086).
The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2015-3927</identifier><identifier>PMID: 26969272</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adult ; Analysis ; Biological Clocks ; Cardiovascular disease ; Correlation analysis ; Diseases ; Fathers ; Female ; Health aspects ; Humans ; Infant, Newborn ; Infants (Newborn) ; Leukocytes ; Male ; Mothers ; Newborn babies ; Newborn infants ; Pediatrics ; Risk factors ; Sex Factors ; Telomere - ultrastructure ; White blood cells</subject><ispartof>Pediatrics (Evanston), 2016-04, Vol.137 (4), p.1-1</ispartof><rights>Copyright © 2016 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Apr 2016</rights><rights>Copyright © 2016 by the American Academy of Pediatrics 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-cd7c9dd829ff49adace0f9b0734d191e95ca1673accaa7f21826c82838eeb4b83</citedby><cites>FETCH-LOGICAL-c555t-cd7c9dd829ff49adace0f9b0734d191e95ca1673accaa7f21826c82838eeb4b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26969272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Factor-Litvak, Pam</creatorcontrib><creatorcontrib>Susser, Ezra</creatorcontrib><creatorcontrib>Kezios, Katrina</creatorcontrib><creatorcontrib>McKeague, Ian</creatorcontrib><creatorcontrib>Kark, Jeremy D</creatorcontrib><creatorcontrib>Hoffman, Matthew</creatorcontrib><creatorcontrib>Kimura, Masayuki</creatorcontrib><creatorcontrib>Wapner, Ronald</creatorcontrib><creatorcontrib>Aviv, Abraham</creatorcontrib><title>Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock," whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns.
LTL was measured in blood samples from 490 newborns and their parents.
LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086).
The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults.</description><subject>Adult</subject><subject>Analysis</subject><subject>Biological Clocks</subject><subject>Cardiovascular disease</subject><subject>Correlation analysis</subject><subject>Diseases</subject><subject>Fathers</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Mothers</subject><subject>Newborn babies</subject><subject>Newborn infants</subject><subject>Pediatrics</subject><subject>Risk factors</subject><subject>Sex Factors</subject><subject>Telomere - ultrastructure</subject><subject>White blood cells</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1v0zAchi0EYqVw5YgsceGS4s_E5oA0lY9NqpiExhXLdX5pMxy7sxNg_z2OOirgxMkHP-8r-9WD0HNKVlQK9voAbV4xQmXFNWseoAUlWlWCNfIhWhDCaSUIkWfoSc43hBAhG_YYnbFa1wVnC_R1A9O36O5GwNfg4wAJ8AbCbtzjPuBP8GMbU8hv8OVw8L2zYx9Dxl1MeNwD_hw94NidknnOXEyDDfhdn8FmeIoeddZneHZ_LtGXD--v1xfV5urj5fp8Uzkp5Vi5tnG6bRXTXSe0ba0D0uktabhoqaagpbO0brh1ztqmY1Sx2immuALYiq3iS_T22HuYtgO0DsKYrDeH1A823Zloe_P3Tej3Zhe_G6Eo5XQueHVfkOLtBHk0Q58deG8DxCkbWjhNeE3-A200l2Xg8t4levkPehOnFMoShVJCS6G1KFR1pHbWg-mDi2GEn6OL3sMOTBlqfWXOhWSE81rVhV8deZdizgm60z8pMbMVZrbCzFaY2YoSePHnOif8twb8F_OMs2M</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Factor-Litvak, Pam</creator><creator>Susser, Ezra</creator><creator>Kezios, Katrina</creator><creator>McKeague, Ian</creator><creator>Kark, Jeremy D</creator><creator>Hoffman, Matthew</creator><creator>Kimura, Masayuki</creator><creator>Wapner, Ronald</creator><creator>Aviv, Abraham</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease</title><author>Factor-Litvak, Pam ; Susser, Ezra ; Kezios, Katrina ; McKeague, Ian ; Kark, Jeremy D ; Hoffman, Matthew ; Kimura, Masayuki ; Wapner, Ronald ; Aviv, Abraham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-cd7c9dd829ff49adace0f9b0734d191e95ca1673accaa7f21826c82838eeb4b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Biological Clocks</topic><topic>Cardiovascular disease</topic><topic>Correlation analysis</topic><topic>Diseases</topic><topic>Fathers</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Mothers</topic><topic>Newborn babies</topic><topic>Newborn infants</topic><topic>Pediatrics</topic><topic>Risk factors</topic><topic>Sex Factors</topic><topic>Telomere - ultrastructure</topic><topic>White blood cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Factor-Litvak, Pam</creatorcontrib><creatorcontrib>Susser, Ezra</creatorcontrib><creatorcontrib>Kezios, Katrina</creatorcontrib><creatorcontrib>McKeague, Ian</creatorcontrib><creatorcontrib>Kark, Jeremy D</creatorcontrib><creatorcontrib>Hoffman, Matthew</creatorcontrib><creatorcontrib>Kimura, Masayuki</creatorcontrib><creatorcontrib>Wapner, Ronald</creatorcontrib><creatorcontrib>Aviv, Abraham</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Factor-Litvak, Pam</au><au>Susser, Ezra</au><au>Kezios, Katrina</au><au>McKeague, Ian</au><au>Kark, Jeremy D</au><au>Hoffman, Matthew</au><au>Kimura, Masayuki</au><au>Wapner, Ronald</au><au>Aviv, Abraham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2016-04</date><risdate>2016</risdate><volume>137</volume><issue>4</issue><spage>1</spage><epage>1</epage><pages>1-1</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock," whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns.
LTL was measured in blood samples from 490 newborns and their parents.
LTL (mean ± SD) was longer (9.50 ± 0.70 kb) in newborns than in their mothers (7.92 ± 0.67 kb) and fathers (7.70 ± 0.71 kb) (both P < .0001); there was no difference in the variance of LTL among the 3 groups. Newborn LTL correlated more strongly with age-adjusted LTL in mothers (r = 0.47; P < .01) than in fathers (r = 0.36; P < .01) (P for interaction = .02). Newborn LTL was longer by 0.144 kb in girls than in boys (P = .02), and LTL was longer by 0.175 kb in mothers than in fathers (P < .0001). For each 1-year increase in father's age, newborn LTL increased by 0.016 kb (95% confidence interval: 0.04 to 0.28) (P = .0086).
The large LTL variation across newborns challenges the telomeric clock model. Having inherently short or long LTL may be largely determined at birth, anteceding by decades disease manifestation in adults.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>26969272</pmid><doi>10.1542/peds.2015-3927</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis Biological Clocks Cardiovascular disease Correlation analysis Diseases Fathers Female Health aspects Humans Infant, Newborn Infants (Newborn) Leukocytes Male Mothers Newborn babies Newborn infants Pediatrics Risk factors Sex Factors Telomere - ultrastructure White blood cells |
| title | Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease |
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