Induction of Epstein-Barr Virus Oncoprotein LMP1 by Transcription Factors AP-2 and Early B Cell Factor

Latent membrane protein 1 (LMP1) is a major oncogene essential for primary B cell transformation by Epstein-Barr virus (EBV). Previous studies suggested that some transcription factors, such as PU.1, RBP-Jκ, NF-κB, and STAT, are involved in this expression, but the underlying mechanism is unclear. H...

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Veröffentlicht in:	Journal of virology 2016-04, Vol.90 (8), p.3873-3889
Hauptverfasser:	Murata, Takayuki, Noda, Chieko, Narita, Yohei, Watanabe, Takahiro, Yoshida, Masahiro, Ashio, Keiji, Sato, Yoshitaka, Goshima, Fumi, Kanda, Teru, Yoshiyama, Hironori, Tsurumi, Tatsuya, Kimura, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cell Transformation, Viral Gene Expression Regulation, Viral HEK293 Cells HeLa Cells Herpesvirus 4, Human - genetics Humans Mutation Oncogenes POU Domain Factors - metabolism Promoter Regions, Genetic Proto-Oncogene Proteins - metabolism Trans-Activators - metabolism Transcription Factor AP-2 - metabolism Transformation and Oncogenesis Viral Matrix Proteins - genetics
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