Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells

When assembling a nephron during development a multipotent stem cell pool becomes restricted as differentiation ensues. A faulty differentiation arrest in this process leads to transformation and initiation of a Wilms’ tumor. Mapping these transitions with respective surface markers affords accessib...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23562-23562, Article 23562
Hauptverfasser:	Pode-Shakked, Naomi, Pleniceanu, Oren, Gershon, Rotem, Shukrun, Rachel, Kanter, Itamar, Bucris, Efrat, Pode-Shakked, Ben, Tam, Gal, Tam, Hadar, Caspi, Revital, Pri-Chen, Sara, Vax, Einav, Katz, Guy, Omer, Dorit, Harari-Steinberg, Orit, Kalisky, Tomer, Dekel, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 14/63 38/77 631/136/532/489 631/136/532/71 64/60 82 96/100 AC133 Antigen - genetics AC133 Antigen - metabolism Animals Biomarkers - metabolism Cancer Carcinogenesis - genetics Carcinogenesis - metabolism CD56 Antigen - genetics CD56 Antigen - metabolism Cell self-renewal Cells, Cultured Child Child, Preschool Female Gene Expression Regulation Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Humans Immunohistochemistry Infant Kidney - embryology Kidney - metabolism Kidneys Male Mapping Mice, Inbred NOD multidisciplinary Negative selection Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Nephrons - cytology Nephrons - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Organogenesis - genetics Prospective Studies Purification Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Science Science (multidisciplinary) Stem cells Stem Cells - metabolism Subpopulations Surface markers Transplantation, Heterologous Tumor Cells, Cultured Tumorigenesis Wilms' tumor Xenografts
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