Clinical Activity of mTOR Inhibition With Sirolimus in Malignant Perivascular Epithelioid Cell Tumors: Targeting the Pathogenic Activation of mTORC1 in Tumors

PURPOSE Perivascular epithelioid cell tumors (PEComas) represent a family of mesenchymal neoplasms, mechanistically linked through activation of the mTOR signaling pathway. There is no known effective therapy for PEComa, and the molecular pathophysiology of aberrant mTOR signaling provided us with a...

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Veröffentlicht in:	Journal of clinical oncology 2010-02, Vol.28 (5), p.835-840
Hauptverfasser:	WAGNER, Andrew J, MALINOWSKA-KOLODZIEJ, Izabela, KWIATKOWSKI, David J, MAKI, Robert G, MORGAN, Jeffrey A, WEI QIN, FLETCHER, Christopher D. M, VENA, Natalie, LIGON, Azra H, ANTONESCU, Cristina R, RAMAIYA, Nikhil H, DEMETRI, George D
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aged Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - therapeutic use Biological and medical sciences Female Humans Immunohistochemistry In Situ Hybridization, Fluorescence Intracellular Signaling Peptides and Proteins - analysis Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Male Mechanistic Target of Rapamycin Complex 1 Medical sciences Middle Aged Multiprotein Complexes Original Reports Perivascular Epithelioid Cell Neoplasms - chemistry Perivascular Epithelioid Cell Neoplasms - diagnostic imaging Perivascular Epithelioid Cell Neoplasms - drug therapy Perivascular Epithelioid Cell Neoplasms - genetics Perivascular Epithelioid Cell Neoplasms - secondary Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - antagonists & inhibitors Proteins Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - therapeutic use Time Factors Tomography, X-Ray Computed TOR Serine-Threonine Kinases Transcription Factors - analysis Transcription Factors - antagonists & inhibitors Treatment Outcome Tumor Suppressor Proteins - analysis Tumor Suppressor Proteins - genetics Tumors United States
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