The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)
Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has rev...
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| Veröffentlicht in: | International journal of oncology 2016-05, Vol.48 (5), p.1772-1782 |
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| container_title | International journal of oncology |
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| creator | CHO, MINSOO SO, INSUK CHUN, JUNG NYEO JEON, JU-HONG |
| description | Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation. |
| doi_str_mv | 10.3892/ijo.2016.3427 |
| format | Article |
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To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2016.3427</identifier><identifier>PMID: 26983575</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Alcohol ; Angiogenesis ; Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antitumor effect ; Apoptosis ; Breast cancer ; Cancer ; cancer hallmark ; Care and treatment ; Cell culture ; Cell cycle ; Colorectal cancer ; Drug dosages ; Drug Resistance, Neoplasm - drug effects ; Gene Expression Regulation, Neoplastic - drug effects ; Genomes ; geraniol ; Health aspects ; Humans ; Kinases ; Liver cancer ; Lung cancer ; Metastasis ; Methods ; molecular mechanism ; Molecular targeted therapy ; Monoterpenes ; Mutation ; Neoplasms - drug therapy ; Neoplasms - metabolism ; Oils & fats ; Prostate ; Signal Transduction - drug effects ; Skin cancer ; Terpenes - pharmacology ; Terpenes - therapeutic use</subject><ispartof>International journal of oncology, 2016-05, Vol.48 (5), p.1772-1782</ispartof><rights>Copyright: © Cho et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Cho et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c611t-20947a45b926c28a061a6664512c60fcef6b9059c87919479bcd0a805378acf33</citedby><cites>FETCH-LOGICAL-c611t-20947a45b926c28a061a6664512c60fcef6b9059c87919479bcd0a805378acf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,5575,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26983575$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHO, MINSOO</creatorcontrib><creatorcontrib>SO, INSUK</creatorcontrib><creatorcontrib>CHUN, JUNG NYEO</creatorcontrib><creatorcontrib>JEON, JU-HONG</creatorcontrib><title>The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.</description><subject>Alcohol</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>antitumor effect</subject><subject>Apoptosis</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>cancer hallmark</subject><subject>Care and treatment</subject><subject>Cell culture</subject><subject>Cell cycle</subject><subject>Colorectal cancer</subject><subject>Drug dosages</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Genomes</subject><subject>geraniol</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>Lung cancer</subject><subject>Metastasis</subject><subject>Methods</subject><subject>molecular mechanism</subject><subject>Molecular targeted therapy</subject><subject>Monoterpenes</subject><subject>Mutation</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Oils & fats</subject><subject>Prostate</subject><subject>Signal Transduction - drug effects</subject><subject>Skin cancer</subject><subject>Terpenes - pharmacology</subject><subject>Terpenes - therapeutic use</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkstr3DAQxk1paB7tsddiKPRx8FZvWz0UQmibQEohpGcxK0trbW1pI9kJ-e8js-k2C0EHiZnffMyMvqJ4i9GCNpJ8ceuwIAiLBWWkflEc4VriijBCX-Y3wrISjMrD4jilNUKEc4RfFYdEyIbymh8VV9edKcGPbpyGEEtjrdFjKoMtVyaCd6H_Wv4K7dTD6IKf4xq8NrHsoO8HiH_LDYzdHdyn8tOVuXXm7vPr4sBCn8ybx_uk-PPj-_XZeXX5--fF2ellpQXGY0WQZDUwvpREaNIAEhiEEIxjogWy2lixlIhL3eSJMiqXukXQIE7rBrSl9KT4ttXdTMvBtNr4MUKvNtHlvu5VAKf2M951ahVuFWuQFLzOAu8fBWK4mUwa1TpM0eeeFZaUUFJLhP9TK-iNct6GLKYHl7Q6ZVyQRgokMrV4hsqnNYPTwRvrcnyv4MOTgs5AP3Yp9NO85rQPVltQx5BSNHY3IUZqtoDKFlCzBdRsgcy_e7qWHf3vzzPwcQukDfjWtSHtmKxUsaZCvMJ1TegDMT23Og</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>CHO, MINSOO</creator><creator>SO, INSUK</creator><creator>CHUN, JUNG NYEO</creator><creator>JEON, JU-HONG</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20160501</creationdate><title>The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)</title><author>CHO, MINSOO ; SO, INSUK ; CHUN, JUNG NYEO ; JEON, JU-HONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-20947a45b926c28a061a6664512c60fcef6b9059c87919479bcd0a805378acf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alcohol</topic><topic>Angiogenesis</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>antitumor effect</topic><topic>Apoptosis</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>cancer hallmark</topic><topic>Care and treatment</topic><topic>Cell culture</topic><topic>Cell cycle</topic><topic>Colorectal cancer</topic><topic>Drug dosages</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Genomes</topic><topic>geraniol</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Kinases</topic><topic>Liver cancer</topic><topic>Lung cancer</topic><topic>Metastasis</topic><topic>Methods</topic><topic>molecular mechanism</topic><topic>Molecular targeted therapy</topic><topic>Monoterpenes</topic><topic>Mutation</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Oils & fats</topic><topic>Prostate</topic><topic>Signal Transduction - drug effects</topic><topic>Skin cancer</topic><topic>Terpenes - pharmacology</topic><topic>Terpenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHO, MINSOO</creatorcontrib><creatorcontrib>SO, INSUK</creatorcontrib><creatorcontrib>CHUN, JUNG NYEO</creatorcontrib><creatorcontrib>JEON, JU-HONG</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHO, MINSOO</au><au>SO, INSUK</au><au>CHUN, JUNG NYEO</au><au>JEON, JU-HONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)</atitle><jtitle>International journal of oncology</jtitle><addtitle>Int J Oncol</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>48</volume><issue>5</issue><spage>1772</spage><epage>1782</epage><pages>1772-1782</pages><issn>1019-6439</issn><eissn>1791-2423</eissn><abstract>Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26983575</pmid><doi>10.3892/ijo.2016.3427</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of oncology, 2016-05, Vol.48 (5), p.1772-1782 |
| issn | 1019-6439 1791-2423 |
| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Alcohol Angiogenesis Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antitumor effect Apoptosis Breast cancer Cancer cancer hallmark Care and treatment Cell culture Cell cycle Colorectal cancer Drug dosages Drug Resistance, Neoplasm - drug effects Gene Expression Regulation, Neoplastic - drug effects Genomes geraniol Health aspects Humans Kinases Liver cancer Lung cancer Metastasis Methods molecular mechanism Molecular targeted therapy Monoterpenes Mutation Neoplasms - drug therapy Neoplasms - metabolism Oils & fats Prostate Signal Transduction - drug effects Skin cancer Terpenes - pharmacology Terpenes - therapeutic use |
| title | The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review) |
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