High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells

Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-throughput assay using H295R human adrenocortical carcinoma cells was used to evaluate the effect of 2060 chemical samples on steroidogenesis v...

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Veröffentlicht in:	Toxicological sciences 2016-04, Vol.150 (2), p.323-332
Hauptverfasser:	Karmaus, Agnes L, Toole, Colleen M, Filer, Dayne L, Lewis, Kenneth C, Martin, Matthew T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocortical Carcinoma - metabolism Adrenocortical Carcinoma - pathology Cell Culture Techniques Cell Line, Tumor Cell Survival - drug effects Chromatography, High Pressure Liquid Dose-Response Relationship, Drug Endocrine Disruptors - toxicity High-Throughput Screening Assays Hormones - biosynthesis Humans Maximum Tolerated Dose Steroids - biosynthesis Tandem Mass Spectrometry Toxicant Screen for Altered Steroid Synthesis
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