Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model
Recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on...
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| Veröffentlicht in: | Nutrients 2016-03, Vol.8 (3), p.146-146 |
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| creator | Choi, Eun-Ju Iwasa, Masahiro Han, Kwon-Il Kim, Wan-Jae Tang, Yujiao Hwang, Young Joung Chae, Jeong Ryong Han, Weon Cheol Shin, Yu-Su Kim, Eun-Kyung |
| description | Recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on AD. We established an in vivo AD model by repeated local exposure of Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB) to the ears of mice. After oral administration of EF-2001 for four weeks, the epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured. In addition, the gene expression levels of pathogenic cytokines in the ears, lymph nodes, and splenocytes were assayed. EF-2001 attenuated AD symptoms based on the ear thickness, histopathological analysis, and serum immunoglobulin levels. Moreover, EF-2001 decreased the DFE/DNCB-induced expression of various pathogenic cytokines in the ears, lymph nodes, and splenocytes. These results suggest that EF-2001 has therapeutic potential in the treatment of AD owing to its immunomodulatory effects. |
| doi_str_mv | 10.3390/nu8030146 |
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Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on AD. We established an in vivo AD model by repeated local exposure of Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB) to the ears of mice. After oral administration of EF-2001 for four weeks, the epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured. In addition, the gene expression levels of pathogenic cytokines in the ears, lymph nodes, and splenocytes were assayed. EF-2001 attenuated AD symptoms based on the ear thickness, histopathological analysis, and serum immunoglobulin levels. Moreover, EF-2001 decreased the DFE/DNCB-induced expression of various pathogenic cytokines in the ears, lymph nodes, and splenocytes. These results suggest that EF-2001 has therapeutic potential in the treatment of AD owing to its immunomodulatory effects.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu8030146</identifier><identifier>PMID: 26959058</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>animal models ; Animals ; atopic dermatitis ; Bacteria ; blood serum ; Cytokines ; Cytokines - immunology ; Cytokines - metabolism ; Dermatitis ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - metabolism ; Dermatitis, Atopic - microbiology ; Dermatitis, Atopic - therapy ; Dermatophagoides farinae ; Dermatophagoides pteronyssinus ; Disease Models, Animal ; dust ; dust mites ; ears ; Ears & hearing ; Enterococcus faecalis ; Enterococcus faecalis - immunology ; Female ; gene expression ; histopathology ; Hot Temperature ; Hyperplasia ; Immunoglobulins ; immunomodulators ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; lactic acid bacteria ; lymph nodes ; Lymphatic system ; mast cells ; mice ; Mice, Inbred BALB C ; oral administration ; Pathogenesis ; Physical education ; Probiotics ; R&D ; Research & development ; Skin - immunology ; Skin - metabolism ; Skin - microbiology ; Skin - pathology ; splenocytes ; Time Factors</subject><ispartof>Nutrients, 2016-03, Vol.8 (3), p.146-146</ispartof><rights>Copyright MDPI AG 2016</rights><rights>2016 by the authors; licensee MDPI, Basel, Switzerland. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-32c0e7504abc3518109e0a692a41708eacdb7d0eb4121479b9d8bae0ed1c00373</citedby><cites>FETCH-LOGICAL-c535t-32c0e7504abc3518109e0a692a41708eacdb7d0eb4121479b9d8bae0ed1c00373</cites><orcidid>0000-0002-4832-6427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808875/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808875/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26959058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Eun-Ju</creatorcontrib><creatorcontrib>Iwasa, Masahiro</creatorcontrib><creatorcontrib>Han, Kwon-Il</creatorcontrib><creatorcontrib>Kim, Wan-Jae</creatorcontrib><creatorcontrib>Tang, Yujiao</creatorcontrib><creatorcontrib>Hwang, Young Joung</creatorcontrib><creatorcontrib>Chae, Jeong Ryong</creatorcontrib><creatorcontrib>Han, Weon Cheol</creatorcontrib><creatorcontrib>Shin, Yu-Su</creatorcontrib><creatorcontrib>Kim, Eun-Kyung</creatorcontrib><title>Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on AD. We established an in vivo AD model by repeated local exposure of Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB) to the ears of mice. After oral administration of EF-2001 for four weeks, the epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured. In addition, the gene expression levels of pathogenic cytokines in the ears, lymph nodes, and splenocytes were assayed. EF-2001 attenuated AD symptoms based on the ear thickness, histopathological analysis, and serum immunoglobulin levels. Moreover, EF-2001 decreased the DFE/DNCB-induced expression of various pathogenic cytokines in the ears, lymph nodes, and splenocytes. These results suggest that EF-2001 has therapeutic potential in the treatment of AD owing to its immunomodulatory effects.</description><subject>animal models</subject><subject>Animals</subject><subject>atopic dermatitis</subject><subject>Bacteria</subject><subject>blood serum</subject><subject>Cytokines</subject><subject>Cytokines - immunology</subject><subject>Cytokines - metabolism</subject><subject>Dermatitis</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - metabolism</subject><subject>Dermatitis, Atopic - microbiology</subject><subject>Dermatitis, Atopic - therapy</subject><subject>Dermatophagoides farinae</subject><subject>Dermatophagoides pteronyssinus</subject><subject>Disease Models, Animal</subject><subject>dust</subject><subject>dust mites</subject><subject>ears</subject><subject>Ears & hearing</subject><subject>Enterococcus faecalis</subject><subject>Enterococcus faecalis - immunology</subject><subject>Female</subject><subject>gene expression</subject><subject>histopathology</subject><subject>Hot Temperature</subject><subject>Hyperplasia</subject><subject>Immunoglobulins</subject><subject>immunomodulators</subject><subject>Inflammation Mediators - immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>lactic acid bacteria</subject><subject>lymph nodes</subject><subject>Lymphatic system</subject><subject>mast cells</subject><subject>mice</subject><subject>Mice, Inbred BALB C</subject><subject>oral administration</subject><subject>Pathogenesis</subject><subject>Physical education</subject><subject>Probiotics</subject><subject>R&D</subject><subject>Research & development</subject><subject>Skin - immunology</subject><subject>Skin - metabolism</subject><subject>Skin - microbiology</subject><subject>Skin - pathology</subject><subject>splenocytes</subject><subject>Time Factors</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1vFDEMhiNERavSA38AReIChwHnO3NBWpXth9qKCxw4RZmMF1LNTJYkg8S_76xaVoUL9cWW_OiV_dqEvGLwXogWPkyzBQFM6mfkiIPhjdZSPH9UH5KTUm5hFwaMFi_IIdetakHZI_LtAn1truIwYE_XU8WcQgphLnTjMfghFro-azgAo6sRh5iyr1joqqZtDPQT5tHXWBcqTtTTmznHCelN6nF4SQ42fih48pCPydez9ZfTi-b68_nl6eq6CUqo2ggeAI0C6bsgFLMMWgSvW-4lM2DRh74zPWAnGWfStF3b284jYM8CgDDimHy8193O3Yh9wKlmP7htjqPPv13y0f3dmeIP9z39ctKCtUYtAm8fBHL6OWOpbowl4DD4CdNcHOdmGUsJZv6LMmO0VpyZ9ikot0JpuxvgzT_obZrztJjmmAUpDePKLtS7eyrkVErGzX5FBm73CW7_CQv7-rEne_LP3cUdvyGrhw</recordid><startdate>20160305</startdate><enddate>20160305</enddate><creator>Choi, Eun-Ju</creator><creator>Iwasa, Masahiro</creator><creator>Han, Kwon-Il</creator><creator>Kim, Wan-Jae</creator><creator>Tang, Yujiao</creator><creator>Hwang, Young Joung</creator><creator>Chae, Jeong Ryong</creator><creator>Han, Weon Cheol</creator><creator>Shin, Yu-Su</creator><creator>Kim, Eun-Kyung</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4832-6427</orcidid></search><sort><creationdate>20160305</creationdate><title>Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model</title><author>Choi, Eun-Ju ; Iwasa, Masahiro ; Han, Kwon-Il ; Kim, Wan-Jae ; Tang, Yujiao ; Hwang, Young Joung ; Chae, Jeong Ryong ; Han, Weon Cheol ; Shin, Yu-Su ; Kim, Eun-Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-32c0e7504abc3518109e0a692a41708eacdb7d0eb4121479b9d8bae0ed1c00373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>animal models</topic><topic>Animals</topic><topic>atopic dermatitis</topic><topic>Bacteria</topic><topic>blood serum</topic><topic>Cytokines</topic><topic>Cytokines - immunology</topic><topic>Cytokines - metabolism</topic><topic>Dermatitis</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - metabolism</topic><topic>Dermatitis, Atopic - microbiology</topic><topic>Dermatitis, Atopic - therapy</topic><topic>Dermatophagoides farinae</topic><topic>Dermatophagoides pteronyssinus</topic><topic>Disease Models, Animal</topic><topic>dust</topic><topic>dust mites</topic><topic>ears</topic><topic>Ears & hearing</topic><topic>Enterococcus faecalis</topic><topic>Enterococcus faecalis - immunology</topic><topic>Female</topic><topic>gene expression</topic><topic>histopathology</topic><topic>Hot Temperature</topic><topic>Hyperplasia</topic><topic>Immunoglobulins</topic><topic>immunomodulators</topic><topic>Inflammation Mediators - immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>lactic acid bacteria</topic><topic>lymph nodes</topic><topic>Lymphatic system</topic><topic>mast cells</topic><topic>mice</topic><topic>Mice, Inbred BALB C</topic><topic>oral administration</topic><topic>Pathogenesis</topic><topic>Physical education</topic><topic>Probiotics</topic><topic>R&D</topic><topic>Research & development</topic><topic>Skin - 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Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Eun-Ju</au><au>Iwasa, Masahiro</au><au>Han, Kwon-Il</au><au>Kim, Wan-Jae</au><au>Tang, Yujiao</au><au>Hwang, Young Joung</au><au>Chae, Jeong Ryong</au><au>Han, Weon Cheol</au><au>Shin, Yu-Su</au><au>Kim, Eun-Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2016-03-05</date><risdate>2016</risdate><volume>8</volume><issue>3</issue><spage>146</spage><epage>146</epage><pages>146-146</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Recent reports have shown the immunomodulatory effect of heat-killed lactic acid bacteria. Atopic dermatitis (AD) is an allergic skin disease, caused by immune dysregulation among other factors. The aim of this study was to assess the effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on AD. We established an in vivo AD model by repeated local exposure of Dermatophagoides farinae extract (DFE; house dust mite extract) and 2,4-dinitrochlorobenzene (DNCB) to the ears of mice. After oral administration of EF-2001 for four weeks, the epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured. In addition, the gene expression levels of pathogenic cytokines in the ears, lymph nodes, and splenocytes were assayed. EF-2001 attenuated AD symptoms based on the ear thickness, histopathological analysis, and serum immunoglobulin levels. Moreover, EF-2001 decreased the DFE/DNCB-induced expression of various pathogenic cytokines in the ears, lymph nodes, and splenocytes. These results suggest that EF-2001 has therapeutic potential in the treatment of AD owing to its immunomodulatory effects.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>26959058</pmid><doi>10.3390/nu8030146</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-4832-6427</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | animal models Animals atopic dermatitis Bacteria blood serum Cytokines Cytokines - immunology Cytokines - metabolism Dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Dermatitis, Atopic - microbiology Dermatitis, Atopic - therapy Dermatophagoides farinae Dermatophagoides pteronyssinus Disease Models, Animal dust dust mites ears Ears & hearing Enterococcus faecalis Enterococcus faecalis - immunology Female gene expression histopathology Hot Temperature Hyperplasia Immunoglobulins immunomodulators Inflammation Mediators - immunology Inflammation Mediators - metabolism lactic acid bacteria lymph nodes Lymphatic system mast cells mice Mice, Inbred BALB C oral administration Pathogenesis Physical education Probiotics R&D Research & development Skin - immunology Skin - metabolism Skin - microbiology Skin - pathology splenocytes Time Factors |
| title | Heat-Killed Enterococcus faecalis EF-2001 Ameliorates Atopic Dermatitis in a Murine Model |
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