Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort

Highlights • Pre-diagnostic salivary SLPI was higher among HNSCC cases than controls. • Among cases, salivary SLPI was positively associated with cigarette smoking. • Among never smokers, high salivary SLPI was not associated risk of HNSCC. • Among smokers, high SLPI was associated with a significan...

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Veröffentlicht in:	Oral oncology 2016-04, Vol.55, p.1-5
Hauptverfasser:	Pierce Campbell, Christine M, Giuliano, Anna R, Torres, B. Nelson, O’Keefe, Michael T, Ingles, Donna J, Anderson, Rebecca L, Teras, Lauren R, Gapstur, Susan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Carcinoma, Squamous Cell - metabolism Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Head and neck cancer Head and Neck Neoplasms - metabolism Hematology, Oncology and Palliative Medicine Humans Innate immunity Male Middle Aged Mouthwash Oral disease Otolaryngology Risk Assessment Risk Factors Saliva - chemistry Secretory Leukocyte Peptidase Inhibitor - analysis Secretory leukocyte protease inhibitor SLPI Smoking - epidemiology United States - epidemiology
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Zusammenfassung:	Highlights • Pre-diagnostic salivary SLPI was higher among HNSCC cases than controls. • Among cases, salivary SLPI was positively associated with cigarette smoking. • Among never smokers, high salivary SLPI was not associated risk of HNSCC. • Among smokers, high SLPI was associated with a significantly higher risk of HNSCC.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2016.02.004