Diet-derived 25-hydroxyvitamin D3 activates vitamin D receptor target gene expression and suppresses EGFR mutant non-small cell lung cancer growth in vitro and in vivo

Epidemiologic studies implicate vitamin D status as a factor that influences growth of EGFR mutant lung cancers. However, laboratory based evidence of the biological effect of vitamin D in this disease is lacking. To fill this knowledge gap, we determined vitamin D receptor (VDR) expression in human...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (1), p.995-1013
Hauptverfasser:	Verone-Boyle, Alissa R, Shoemaker, Suzanne, Attwood, Kristopher, Morrison, Carl D, Makowski, Andrew J, Battaglia, Sebastiano, Hershberger, Pamela A
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase - genetics 25-Hydroxyvitamin D3 1-alpha-Hydroxylase - metabolism Animals Blotting, Western Calcifediol - administration & dosage Calcifediol - pharmacology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Diet Female Gene Expression Regulation, Neoplastic - drug effects Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice, Nude Mutation Receptor, Epidermal Growth Factor - agonists Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction RNA Interference Transplantation, Heterologous Tumor Burden - drug effects Tumor Burden - genetics
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