Atracurium Besylate and other neuromuscular blocking agents promote astroglial differentiation and deplete glioblastoma stem cells

Glioblastoma multiforme (GBM) are the most common primary malignant brain tumor in adults, with a median survival of about one year. This poor prognosis is attributed primarily to therapeutic resistance and tumor recurrence after surgical removal, with the root cause suggested to be found in gliobla...

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Veröffentlicht in:	Oncotarget 2016-01, Vol.7 (1), p.459-472
Hauptverfasser:	Spina, Raffaella, Voss, Dillon M, Asnaghi, Laura, Sloan, Andrew, Bar, Eli E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - metabolism Astrocytes - pathology Atracurium - pharmacology Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Blotting, Western Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain Neoplasms - metabolism Cell Differentiation - drug effects Cell Line, Tumor Gene Expression Regulation, Neoplastic Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Mice, Nude Microscopy, Fluorescence Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neuromuscular Blocking Agents - pharmacology Receptors, Cholinergic - genetics Receptors, Cholinergic - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Research Paper Reverse Transcriptase Polymerase Chain Reaction Transcription Factor HES-1 Xenograft Model Antitumor Assays
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