Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents
Oxidative stress has been suggested as a major cause of elevated blood pressure (BP) and reduced heart rate variability (HRV) due to air pollution. We hypothesized that the associations of air pollution exposure with BP and HRV are modified by oxidative stress gene polymorphisms. Between 2008 and 20...
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| Veröffentlicht in: | Environmental health 2016-03, Vol.15 (1), p.47-47, Article 47 |
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| creator | Kim, Kyoung-Nam Kim, Jin Hee Jung, Kweon Hong, Yun-Chul |
| description | Oxidative stress has been suggested as a major cause of elevated blood pressure (BP) and reduced heart rate variability (HRV) due to air pollution. We hypothesized that the associations of air pollution exposure with BP and HRV are modified by oxidative stress gene polymorphisms.
Between 2008 and 2010, we conducted up to 5 surveys of 547 elderly participants, measured their BP and HRV, and genotyped 47 single nucleotide polymorphisms (SNPs) in 18 oxidative stress genes. Linear mixed models were constructed to evaluate the associations of particulate matter ≤10 μm, nitrogen dioxide, and sulfur dioxide with BP and HRV, as well as the modifications of these associations by the genotyped SNPs.
Single-SNP analyses revealed interactions between air pollution and 15 SNPs (for BP) and 33 SNPs (for HRV) (all, P for interaction |
| doi_str_mv | 10.1186/s12940-016-0130-3 |
| format | Article |
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Between 2008 and 2010, we conducted up to 5 surveys of 547 elderly participants, measured their BP and HRV, and genotyped 47 single nucleotide polymorphisms (SNPs) in 18 oxidative stress genes. Linear mixed models were constructed to evaluate the associations of particulate matter ≤10 μm, nitrogen dioxide, and sulfur dioxide with BP and HRV, as well as the modifications of these associations by the genotyped SNPs.
Single-SNP analyses revealed interactions between air pollution and 15 SNPs (for BP) and 33 SNPs (for HRV) (all, P for interaction < 0.05). When we generated genetic risk scores for BP and HRV, using the SNPs with interactions in the single-SNP models, we found that associations of air pollution exposure with BP and HRV were modified by the genetic risk scores (P for interaction < 0.05).
These results strongly suggest that the associations of air pollution with BP and HRV are mediated by oxidative stress pathways.</description><identifier>ISSN: 1476-069X</identifier><identifier>EISSN: 1476-069X</identifier><identifier>DOI: 10.1186/s12940-016-0130-3</identifier><identifier>PMID: 27015811</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Air Pollutants - toxicity ; Air pollution ; Air Pollution - adverse effects ; Analysis ; Blood Pressure - drug effects ; Cities ; Environmental Exposure - adverse effects ; Environmental health ; Female ; Genetic aspects ; Health aspects ; Heart beat ; Heart Rate - drug effects ; Humans ; Korea ; Male ; Nitrogen Dioxide - toxicity ; Oxidative stress ; Oxidative Stress - genetics ; Particulate Matter - toxicity ; Polymorphism, Single Nucleotide ; Risk factors ; Single nucleotide polymorphisms ; Sulfur Dioxide - toxicity</subject><ispartof>Environmental health, 2016-03, Vol.15 (1), p.47-47, Article 47</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Kim et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-884a1532bac0563fc4a561560f682fc4ab6b442bded1d9f1412aa8a8e643ec093</citedby><cites>FETCH-LOGICAL-c494t-884a1532bac0563fc4a561560f682fc4ab6b442bded1d9f1412aa8a8e643ec093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807581/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807581/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27015811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Kyoung-Nam</creatorcontrib><creatorcontrib>Kim, Jin Hee</creatorcontrib><creatorcontrib>Jung, Kweon</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><title>Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents</title><title>Environmental health</title><addtitle>Environ Health</addtitle><description>Oxidative stress has been suggested as a major cause of elevated blood pressure (BP) and reduced heart rate variability (HRV) due to air pollution. We hypothesized that the associations of air pollution exposure with BP and HRV are modified by oxidative stress gene polymorphisms.
Between 2008 and 2010, we conducted up to 5 surveys of 547 elderly participants, measured their BP and HRV, and genotyped 47 single nucleotide polymorphisms (SNPs) in 18 oxidative stress genes. Linear mixed models were constructed to evaluate the associations of particulate matter ≤10 μm, nitrogen dioxide, and sulfur dioxide with BP and HRV, as well as the modifications of these associations by the genotyped SNPs.
Single-SNP analyses revealed interactions between air pollution and 15 SNPs (for BP) and 33 SNPs (for HRV) (all, P for interaction < 0.05). When we generated genetic risk scores for BP and HRV, using the SNPs with interactions in the single-SNP models, we found that associations of air pollution exposure with BP and HRV were modified by the genetic risk scores (P for interaction < 0.05).
These results strongly suggest that the associations of air pollution with BP and HRV are mediated by oxidative stress pathways.</description><subject>Aged</subject><subject>Air Pollutants - toxicity</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Analysis</subject><subject>Blood Pressure - drug effects</subject><subject>Cities</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental health</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Heart beat</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Korea</subject><subject>Male</subject><subject>Nitrogen Dioxide - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - genetics</subject><subject>Particulate Matter - toxicity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Sulfur Dioxide - toxicity</subject><issn>1476-069X</issn><issn>1476-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUk1v1DAQjRCIlsIP4IIsceGSYieO43BAWlV8SZW4gMTNmtiTXVeOHexk6f4w_h8OW0qLkGXZM_PeG83oFcVzRs8Zk-J1YlXHaUmZyLemZf2gOGW8zZHovj288z8pnqR0RSlrpWgeFydVS1kjGTstfm5SCtrCbINPJAwEbCRTcG5ZMwSvp5CWiOSHnXekdyEYMkVMv3PgDdkhxJlEmJHsIVrorbPzgUAuj8HYwaIh_YGEa2tyjz2SNK90skWP6Q3ZkIgTZrYpR4RVNZEJPDoCY_Bbgs5gdAeyxB58xiZr0M_pafFoAJfw2c17Vnx9_-7Lxcfy8vOHTxeby1Lzjs-llBxYU1c9aNqIetAcGsEaQQchqzXqRc951Rs0zHQD46wCkCBR8Bo17eqz4u1Rd1r6EY3OvSM4NUU7QjyoAFbdr3i7U9uwV1zSNi84C7y6EYjh-4JpVqNNGp3LM4YlKda2QlRS1DJDX_4DvQpL9Hm8jOpa2QkuxF_UFhwq64eQ--pVVG24YLJlTbWizv-DysfgaHXwONicv0dgR4KOIaWIw-2MjKrVa-roNZW9plavqTpzXtxdzi3jj7nqX6La08A</recordid><startdate>20160325</startdate><enddate>20160325</enddate><creator>Kim, Kyoung-Nam</creator><creator>Kim, Jin Hee</creator><creator>Jung, Kweon</creator><creator>Hong, Yun-Chul</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160325</creationdate><title>Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents</title><author>Kim, Kyoung-Nam ; Kim, Jin Hee ; Jung, Kweon ; Hong, Yun-Chul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c494t-884a1532bac0563fc4a561560f682fc4ab6b442bded1d9f1412aa8a8e643ec093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Air Pollutants - toxicity</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Analysis</topic><topic>Blood Pressure - drug effects</topic><topic>Cities</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental health</topic><topic>Female</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Heart beat</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Korea</topic><topic>Male</topic><topic>Nitrogen Dioxide - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - genetics</topic><topic>Particulate Matter - toxicity</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Sulfur Dioxide - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kyoung-Nam</creatorcontrib><creatorcontrib>Kim, Jin Hee</creatorcontrib><creatorcontrib>Jung, Kweon</creatorcontrib><creatorcontrib>Hong, Yun-Chul</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kyoung-Nam</au><au>Kim, Jin Hee</au><au>Jung, Kweon</au><au>Hong, Yun-Chul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents</atitle><jtitle>Environmental health</jtitle><addtitle>Environ Health</addtitle><date>2016-03-25</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>47</spage><epage>47</epage><pages>47-47</pages><artnum>47</artnum><issn>1476-069X</issn><eissn>1476-069X</eissn><abstract>Oxidative stress has been suggested as a major cause of elevated blood pressure (BP) and reduced heart rate variability (HRV) due to air pollution. We hypothesized that the associations of air pollution exposure with BP and HRV are modified by oxidative stress gene polymorphisms.
Between 2008 and 2010, we conducted up to 5 surveys of 547 elderly participants, measured their BP and HRV, and genotyped 47 single nucleotide polymorphisms (SNPs) in 18 oxidative stress genes. Linear mixed models were constructed to evaluate the associations of particulate matter ≤10 μm, nitrogen dioxide, and sulfur dioxide with BP and HRV, as well as the modifications of these associations by the genotyped SNPs.
Single-SNP analyses revealed interactions between air pollution and 15 SNPs (for BP) and 33 SNPs (for HRV) (all, P for interaction < 0.05). When we generated genetic risk scores for BP and HRV, using the SNPs with interactions in the single-SNP models, we found that associations of air pollution exposure with BP and HRV were modified by the genetic risk scores (P for interaction < 0.05).
These results strongly suggest that the associations of air pollution with BP and HRV are mediated by oxidative stress pathways.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27015811</pmid><doi>10.1186/s12940-016-0130-3</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Air Pollutants - toxicity Air pollution Air Pollution - adverse effects Analysis Blood Pressure - drug effects Cities Environmental Exposure - adverse effects Environmental health Female Genetic aspects Health aspects Heart beat Heart Rate - drug effects Humans Korea Male Nitrogen Dioxide - toxicity Oxidative stress Oxidative Stress - genetics Particulate Matter - toxicity Polymorphism, Single Nucleotide Risk factors Single nucleotide polymorphisms Sulfur Dioxide - toxicity |
| title | Associations of air pollution exposure with blood pressure and heart rate variability are modified by oxidative stress genes: A repeated-measures panel among elderly urban residents |
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