Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ

Cone snail toxins are well known blockers of voltage-gated sodium channels, a property that is of broad interest in biology and therapeutically in treating neuropathic pain and neurological disorders. Although most conotoxin channel blockers function by direct binding to a channel and disrupting its...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2016-03, Vol.291 (13), p.7205-7220
Hauptverfasser:	Green, Brad R., Gajewiak, Joanna, Chhabra, Sandeep, Skalicky, Jack J., Zhang, Min-Min, Rivier, Jean E., Bulaj, Grzegorz, Olivera, Baldomero M., Yoshikami, Doju, Norton, Raymond S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding Sites conotoxin Conotoxins - chemical synthesis Conotoxins - chemistry Crystallography, X-Ray cysteine disulfide Disulfides - chemistry Gene Expression high performance liquid chromatography (HPLC) Models, Molecular Molecular Sequence Data Muscle Proteins - chemistry Muscle Proteins - genetics Muscle Proteins - metabolism Mutation NAV1.2 Voltage-Gated Sodium Channel - chemistry NAV1.2 Voltage-Gated Sodium Channel - genetics NAV1.2 Voltage-Gated Sodium Channel - metabolism nuclear magnetic resonance (NMR) peptide chemical synthesis Protein Binding Protein Structure and Folding Protein Structure, Secondary Protein Structure, Tertiary Rats Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Snails - chemistry sodium channel Sodium Channel Blockers - chemical synthesis Sodium Channel Blockers - chemistry Sodium Channels - chemistry Sodium Channels - genetics Sodium Channels - metabolism Solid-Phase Synthesis Techniques Structure-Activity Relationship structure-activity relationship studies two-electrode voltage clamp electrophysiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!