The BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea

Primary dysmenorrhea (PDM), menstrual pain without an organic cause, is a prevailing problem in women of reproductive age. We previously reported alterations of structure and functional connectivity (FC) in the periaqueductal gray (PAG) of PDM subjects. Given that the brain derived neurotrophic fact...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23639-23639, Article 23639
Hauptverfasser:	Wei, Shyh-Yuh, Chao, Hsiang-Tai, Tu, Cheng-Hao, Lin, Ming-Wei, Li, Wei-Chi, Low, Intan, Shen, Horng-Der, Chen, Li-Fen, Hsieh, Jen-Chuen
Format:	Artikel
Sprache:	eng
Schlagworte:	45/77 59/57 631/378/1689/2610 631/378/2583 692/1807/410/2610 692/420/2489/144 Adult Brain Mapping Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Chronic pain Dysmenorrhea - physiopathology Female Functional magnetic resonance imaging Gene polymorphism Genotyping Humanities and Social Sciences Humans Menstruation Methionine - genetics multidisciplinary Neural networks Neuroimaging Pain Pain - physiopathology Periaqueductal gray area Polymorphism, Single Nucleotide Science Science (multidisciplinary) Single-nucleotide polymorphism Valine - genetics Young Adult
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