Semi-automated counting of axon regeneration in poly(lactide co-glycolide) spinal cord bridges

•Hessian-based filtering improves the image contrast of spinal cord axon staining.•Axons can be detected within the filtered images with accurate, automated counting.•Filtering and semi-automated counting effectively estimates the number of myelinated axons. Spinal cord injury (SCI) is a debilitatin...

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Veröffentlicht in:	Journal of neuroscience methods 2016-04, Vol.263, p.15-22
Hauptverfasser:	McCreedy, Dylan A., Margul, Daniel J., Seidlits, Stephanie K., Antane, Jennifer T., Thomas, Ryan J., Sissman, Gillian M., Boehler, Ryan M., Smith, Dominique R., Goldsmith, Sam W., Kukushliev, Todor V., Lamano, Jonathan B., Vedia, Bansi H., He, Ting, Shea, Lonnie D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Automated quantification Automatic Data Processing Axons - pathology Axons - physiology Axons - ultrastructure Biocompatible Materials - therapeutic use Female Hessian filter Lactic Acid - therapeutic use Mice Mice, Inbred C57BL Microscopy, Electron Myelin Basic Protein - metabolism Myelination Nerve Regeneration - physiology Neurofilament Proteins - metabolism Polyglycolic Acid - therapeutic use Spinal Cord Injuries - physiopathology Spinal Cord Injuries - surgery Spinal cord injury
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