Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children
There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NGAL) levels can be considered as an early sign of diabetic kid...
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| Veröffentlicht in: | Journal of clinical research in pediatric endocrinology 2015-12, Vol.7 (4), p.274-279 |
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| container_title | Journal of clinical research in pediatric endocrinology |
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| creator | Yürük Yıldırım, Zeynep Nayır, Ahmet Yılmaz, Alev Gedikbaşı, Asuman Bundak, Rüveyde |
| description | There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NGAL) levels can be considered as an early sign of diabetic kidney injury.
Urine NGAL (uNGAL) levels and urinary NGAL/creatinine ratio (uNGAL/Cr) were assessed in 76 patients with T1DM and compared with the findings of 35 healthy individuals. The relationship of uNGAL levels with diabetes duration, body mass index (BMI), serum lipids, HbA1c, and microalbuminuria was also evaluated.
Mean uNGAL (100.16±108.28 ng/mL) and uNGAL/Cr (118.93-117.97 ng/mg) levels in both microalbuminuric and non-microalbuminuric diabetic patients were found to be higher than those in the control group (uNGAL: 21.46±18.59 ng/mL and uNGAL/Cr: 32.1±51.48 ng/mg) (p=0.0001).
Urine NGAL level increases in the very early phase of T1DM before microalbuminuria develops. The patients with T1DM should be considered to have diabetic kidney injury from the time of diagnosis on and preventive interventions need to be initiated at an early stage to preclude the progression to end-stage renal disease. |
| doi_str_mv | 10.4274/jcrpe.2002 |
| format | Article |
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Urine NGAL (uNGAL) levels and urinary NGAL/creatinine ratio (uNGAL/Cr) were assessed in 76 patients with T1DM and compared with the findings of 35 healthy individuals. The relationship of uNGAL levels with diabetes duration, body mass index (BMI), serum lipids, HbA1c, and microalbuminuria was also evaluated.
Mean uNGAL (100.16±108.28 ng/mL) and uNGAL/Cr (118.93-117.97 ng/mg) levels in both microalbuminuric and non-microalbuminuric diabetic patients were found to be higher than those in the control group (uNGAL: 21.46±18.59 ng/mL and uNGAL/Cr: 32.1±51.48 ng/mg) (p=0.0001).
Urine NGAL level increases in the very early phase of T1DM before microalbuminuria develops. The patients with T1DM should be considered to have diabetic kidney injury from the time of diagnosis on and preventive interventions need to be initiated at an early stage to preclude the progression to end-stage renal disease.</description><identifier>ISSN: 1308-5727</identifier><identifier>EISSN: 1308-5735</identifier><identifier>DOI: 10.4274/jcrpe.2002</identifier><identifier>PMID: 26777038</identifier><language>eng</language><publisher>Turkey: Galenos Publishing House</publisher><subject>Acute-Phase Proteins - urine ; Adolescent ; Albuminuria - urine ; Child ; Diabetes Mellitus, Type 1 - urine ; Diabetic Nephropathies - urine ; Female ; Humans ; Lipocalin-2 ; Lipocalins - urine ; Male ; Original ; Proto-Oncogene Proteins - urine</subject><ispartof>Journal of clinical research in pediatric endocrinology, 2015-12, Vol.7 (4), p.274-279</ispartof><rights>Copyright Galenos Yayinevi Dec 2015</rights><rights>Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-8331dddd84473bd39ae79d0da39fbd27d16b4f04c12447de31264001bf15f45a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805223/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805223/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26777038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yürük Yıldırım, Zeynep</creatorcontrib><creatorcontrib>Nayır, Ahmet</creatorcontrib><creatorcontrib>Yılmaz, Alev</creatorcontrib><creatorcontrib>Gedikbaşı, Asuman</creatorcontrib><creatorcontrib>Bundak, Rüveyde</creatorcontrib><title>Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children</title><title>Journal of clinical research in pediatric endocrinology</title><addtitle>J Clin Res Pediatr Endocrinol</addtitle><description>There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NGAL) levels can be considered as an early sign of diabetic kidney injury.
Urine NGAL (uNGAL) levels and urinary NGAL/creatinine ratio (uNGAL/Cr) were assessed in 76 patients with T1DM and compared with the findings of 35 healthy individuals. The relationship of uNGAL levels with diabetes duration, body mass index (BMI), serum lipids, HbA1c, and microalbuminuria was also evaluated.
Mean uNGAL (100.16±108.28 ng/mL) and uNGAL/Cr (118.93-117.97 ng/mg) levels in both microalbuminuric and non-microalbuminuric diabetic patients were found to be higher than those in the control group (uNGAL: 21.46±18.59 ng/mL and uNGAL/Cr: 32.1±51.48 ng/mg) (p=0.0001).
Urine NGAL level increases in the very early phase of T1DM before microalbuminuria develops. The patients with T1DM should be considered to have diabetic kidney injury from the time of diagnosis on and preventive interventions need to be initiated at an early stage to preclude the progression to end-stage renal disease.</description><subject>Acute-Phase Proteins - urine</subject><subject>Adolescent</subject><subject>Albuminuria - urine</subject><subject>Child</subject><subject>Diabetes Mellitus, Type 1 - urine</subject><subject>Diabetic Nephropathies - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Lipocalin-2</subject><subject>Lipocalins - urine</subject><subject>Male</subject><subject>Original</subject><subject>Proto-Oncogene Proteins - urine</subject><issn>1308-5727</issn><issn>1308-5735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkc1LHTEUxYNUVNRN_4AS6EYKo_mczGwEebVWfLQL7TrcSTKax7xkTGaE9983fj1qz-ZeuD8O53IQ-kzJqWBKnK1MGt0pI4TtoAPKSVNJxeWn7c7UPjrOeUWKhFBEyj20z2qlFOHNAYJfbp5SHB_8gK_cAJMPkF11kXM0HiZn8dKP0cDgA4aMIeBLSMMG3_r7gGOPv3vo3OQNvvE2uA2-Dqs5bXChF8XSJheO0G4PQ3bHb_MQ_flxebf4WS1_X10vLpaVEaSeqoZzaouaEpJ3lrfgVGuJBd72nWXK0roTPRGGskJYxymrBSG066nshQR-iM5ffce5WztrXJgSDHpMfg1poyN4_fES_IO-j09aNEQyxovByZtBio-zy5Ne-2zcMEBwcc6aqpo0daukLOjX_9BVnFMo7xWqaSVlLa0L9e2VMinmnFy_DUOJfi5Pv5Snn8sr8Jd_42_R96r4X0czldc</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Yürük Yıldırım, Zeynep</creator><creator>Nayır, Ahmet</creator><creator>Yılmaz, Alev</creator><creator>Gedikbaşı, Asuman</creator><creator>Bundak, Rüveyde</creator><general>Galenos Publishing House</general><general>Galenos Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20151201</creationdate><title>Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children</title><author>Yürük Yıldırım, Zeynep ; Nayır, Ahmet ; Yılmaz, Alev ; Gedikbaşı, Asuman ; Bundak, Rüveyde</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-8331dddd84473bd39ae79d0da39fbd27d16b4f04c12447de31264001bf15f45a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute-Phase Proteins - urine</topic><topic>Adolescent</topic><topic>Albuminuria - urine</topic><topic>Child</topic><topic>Diabetes Mellitus, Type 1 - urine</topic><topic>Diabetic Nephropathies - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Lipocalin-2</topic><topic>Lipocalins - urine</topic><topic>Male</topic><topic>Original</topic><topic>Proto-Oncogene Proteins - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yürük Yıldırım, Zeynep</creatorcontrib><creatorcontrib>Nayır, Ahmet</creatorcontrib><creatorcontrib>Yılmaz, Alev</creatorcontrib><creatorcontrib>Gedikbaşı, Asuman</creatorcontrib><creatorcontrib>Bundak, Rüveyde</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical research in pediatric endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yürük Yıldırım, Zeynep</au><au>Nayır, Ahmet</au><au>Yılmaz, Alev</au><au>Gedikbaşı, Asuman</au><au>Bundak, Rüveyde</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children</atitle><jtitle>Journal of clinical research in pediatric endocrinology</jtitle><addtitle>J Clin Res Pediatr Endocrinol</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>7</volume><issue>4</issue><spage>274</spage><epage>279</epage><pages>274-279</pages><issn>1308-5727</issn><eissn>1308-5735</eissn><abstract>There is some evidence indicating that histopathological changes in type 1 diabetes mellitus (T1DM) emerge before onset of microalbuminuria. The aim of our study was to determine whether urine neutrophil gelatinase-associated lipocalin (NGAL) levels can be considered as an early sign of diabetic kidney injury.
Urine NGAL (uNGAL) levels and urinary NGAL/creatinine ratio (uNGAL/Cr) were assessed in 76 patients with T1DM and compared with the findings of 35 healthy individuals. The relationship of uNGAL levels with diabetes duration, body mass index (BMI), serum lipids, HbA1c, and microalbuminuria was also evaluated.
Mean uNGAL (100.16±108.28 ng/mL) and uNGAL/Cr (118.93-117.97 ng/mg) levels in both microalbuminuric and non-microalbuminuric diabetic patients were found to be higher than those in the control group (uNGAL: 21.46±18.59 ng/mL and uNGAL/Cr: 32.1±51.48 ng/mg) (p=0.0001).
Urine NGAL level increases in the very early phase of T1DM before microalbuminuria develops. The patients with T1DM should be considered to have diabetic kidney injury from the time of diagnosis on and preventive interventions need to be initiated at an early stage to preclude the progression to end-stage renal disease.</abstract><cop>Turkey</cop><pub>Galenos Publishing House</pub><pmid>26777038</pmid><doi>10.4274/jcrpe.2002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1308-5727 |
| ispartof | Journal of clinical research in pediatric endocrinology, 2015-12, Vol.7 (4), p.274-279 |
| issn | 1308-5727 1308-5735 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acute-Phase Proteins - urine Adolescent Albuminuria - urine Child Diabetes Mellitus, Type 1 - urine Diabetic Nephropathies - urine Female Humans Lipocalin-2 Lipocalins - urine Male Original Proto-Oncogene Proteins - urine |
| title | Neutrophil Gelatinase-Associated Lipocalin as an Early Sign of Diabetic Kidney Injury in Children |
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