Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF-7 cells by reducing FGF4 protein expression
The present study aimed to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) that had been pretreated with pioglitazone and/or rosiglitazone on the growth and proliferation rate of MCF-7 cells. The adhesive interaction between the BMSCs and the MCF-7 cancer cells revealed...
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| Veröffentlicht in: | Molecular medicine reports 2016-04, Vol.13 (4), p.3406-3414 |
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| creator | KHOO, BOON-YIN NADARAJAN, KALPANAH SHIM, SIANG-YIAN MISWAN, NOORIZAN ZANG, CHUAN-BING POSSINGER, KURT ELSTNER, ELENA |
| description | The present study aimed to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) that had been pretreated with pioglitazone and/or rosiglitazone on the growth and proliferation rate of MCF-7 cells. The adhesive interaction between the BMSCs and the MCF-7 cancer cells revealed that the pretreatment of BMSCs with a combination of two types of thiazolidinedione drug reduced the growth and proliferation rate of the MCF-7 cells. The proliferation rate of the MCF-7 cells could also be reduced by the non-adhesive interaction of the cancer cells with BMSCs pretreated with pioglitazone and/or rosiglitazone. The growth and proliferation rate reduction effects on the MCF-7 cells may be attributed to the reduction in the protein level of fibroblast growth factor 4 (FGF4) in the conditioned medium of the pretreated BMSCs. The evidence that the low protein level of FGF4 in the conditioned medium of the pretreated BMSCs perturbed the proliferation rate of the MCF-7 cells by reducing the levels of Ki-67 and proliferating cell nuclear antigen transcripts in the cancer cells was also demonstrated in the present study using a FGF4-neutralizing antibody. All the above findings demonstrate that future studies on the correlation between FGF4 and pretreated BMSCs would be beneficial. |
| doi_str_mv | 10.3892/mmr.2016.4959 |
| format | Article |
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The adhesive interaction between the BMSCs and the MCF-7 cancer cells revealed that the pretreatment of BMSCs with a combination of two types of thiazolidinedione drug reduced the growth and proliferation rate of the MCF-7 cells. The proliferation rate of the MCF-7 cells could also be reduced by the non-adhesive interaction of the cancer cells with BMSCs pretreated with pioglitazone and/or rosiglitazone. The growth and proliferation rate reduction effects on the MCF-7 cells may be attributed to the reduction in the protein level of fibroblast growth factor 4 (FGF4) in the conditioned medium of the pretreated BMSCs. The evidence that the low protein level of FGF4 in the conditioned medium of the pretreated BMSCs perturbed the proliferation rate of the MCF-7 cells by reducing the levels of Ki-67 and proliferating cell nuclear antigen transcripts in the cancer cells was also demonstrated in the present study using a FGF4-neutralizing antibody. All the above findings demonstrate that future studies on the correlation between FGF4 and pretreated BMSCs would be beneficial.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2016.4959</identifier><identifier>PMID: 26934829</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Adhesives ; Bone marrow ; Bone Marrow Cells - cytology ; bone marrow-derived mesenchymal stem cells ; Breast cancer ; Cancer ; Cancer therapies ; Cell growth ; Cell proliferation ; Cell Proliferation - drug effects ; Cells, Cultured ; Chemokines - genetics ; Chemokines - metabolism ; Coculture Techniques ; Culture Media, Conditioned - pharmacology ; Cytokines - genetics ; Cytokines - metabolism ; Down-Regulation - drug effects ; FGF4 ; Fibroblast growth factor 4 ; Fibroblast Growth Factor 4 - genetics ; Fibroblast Growth Factor 4 - metabolism ; Fibroblast growth factors ; Fibroblasts ; Gene Expression Regulation - drug effects ; Glucose ; Growth ; Growth factors ; Humans ; Ki-67 Antigen - metabolism ; Laboratories ; MCF-7 ; MCF-7 Cells ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - drug effects ; Mesenchymal Stromal Cells - metabolism ; Mesenchyme ; Metastasis ; Morphology ; Observations ; Penicillin ; Pioglitazone ; Prescription drugs ; Proliferating cell nuclear antigen ; Proliferating Cell Nuclear Antigen - metabolism ; proliferation rate ; Properties ; Proteins ; Rosiglitazone ; Stem cells ; stem- and -cancer cell interaction ; Studies ; Thiazolidinediones ; Thiazolidinediones - pharmacology ; TZD solution</subject><ispartof>Molecular medicine reports, 2016-04, Vol.13 (4), p.3406-3414</ispartof><rights>Copyright: © Khoo et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Khoo et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-28569a1173a123a5673a138c2018d4711de0d437e7b8554097179480313b90653</citedby><cites>FETCH-LOGICAL-c475t-28569a1173a123a5673a138c2018d4711de0d437e7b8554097179480313b90653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26934829$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KHOO, BOON-YIN</creatorcontrib><creatorcontrib>NADARAJAN, KALPANAH</creatorcontrib><creatorcontrib>SHIM, SIANG-YIAN</creatorcontrib><creatorcontrib>MISWAN, NOORIZAN</creatorcontrib><creatorcontrib>ZANG, CHUAN-BING</creatorcontrib><creatorcontrib>POSSINGER, KURT</creatorcontrib><creatorcontrib>ELSTNER, ELENA</creatorcontrib><title>Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF-7 cells by reducing FGF4 protein expression</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>The present study aimed to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) that had been pretreated with pioglitazone and/or rosiglitazone on the growth and proliferation rate of MCF-7 cells. The adhesive interaction between the BMSCs and the MCF-7 cancer cells revealed that the pretreatment of BMSCs with a combination of two types of thiazolidinedione drug reduced the growth and proliferation rate of the MCF-7 cells. The proliferation rate of the MCF-7 cells could also be reduced by the non-adhesive interaction of the cancer cells with BMSCs pretreated with pioglitazone and/or rosiglitazone. The growth and proliferation rate reduction effects on the MCF-7 cells may be attributed to the reduction in the protein level of fibroblast growth factor 4 (FGF4) in the conditioned medium of the pretreated BMSCs. The evidence that the low protein level of FGF4 in the conditioned medium of the pretreated BMSCs perturbed the proliferation rate of the MCF-7 cells by reducing the levels of Ki-67 and proliferating cell nuclear antigen transcripts in the cancer cells was also demonstrated in the present study using a FGF4-neutralizing antibody. All the above findings demonstrate that future studies on the correlation between FGF4 and pretreated BMSCs would be beneficial.</description><subject>Adhesives</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - cytology</subject><subject>bone marrow-derived mesenchymal stem cells</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells, Cultured</subject><subject>Chemokines - genetics</subject><subject>Chemokines - metabolism</subject><subject>Coculture Techniques</subject><subject>Culture Media, Conditioned - pharmacology</subject><subject>Cytokines - genetics</subject><subject>Cytokines - metabolism</subject><subject>Down-Regulation - drug effects</subject><subject>FGF4</subject><subject>Fibroblast growth factor 4</subject><subject>Fibroblast Growth Factor 4 - genetics</subject><subject>Fibroblast Growth Factor 4 - metabolism</subject><subject>Fibroblast growth factors</subject><subject>Fibroblasts</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glucose</subject><subject>Growth</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Laboratories</subject><subject>MCF-7</subject><subject>MCF-7 Cells</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - drug effects</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Metastasis</subject><subject>Morphology</subject><subject>Observations</subject><subject>Penicillin</subject><subject>Pioglitazone</subject><subject>Prescription drugs</subject><subject>Proliferating cell nuclear antigen</subject><subject>Proliferating Cell Nuclear Antigen - metabolism</subject><subject>proliferation rate</subject><subject>Properties</subject><subject>Proteins</subject><subject>Rosiglitazone</subject><subject>Stem cells</subject><subject>stem- and -cancer cell interaction</subject><subject>Studies</subject><subject>Thiazolidinediones</subject><subject>Thiazolidinediones - pharmacology</subject><subject>TZD solution</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc-P1CAYhonRuOvo0ash8aAXRihQ4GKyzjqryW40cb14IUz7dYZNWyq0rhv_eakzjj9OkPB8Lzy8CD1ldMm1KV51XVwWlJVLYaS5h06ZMoxwSsX9w74wRp2gRyndUFrKQpqH6KQoDRe6MKfox8cIYwQ3dtCPODT4zdWnVcK3ftzh6y_nOIV2Gn3ocQ1VxhIkPO4ADzG0voHofp3lBebZq9WaKFxB2ya8ucMR6qny_RavL9ZiHhnB9xi-DxFSynOP0YPGtQmeHNYF-rx-e716Ry4_XLxfnV2SSig5kkLL0jjGFHes4E6W84brKlvrWijGaqC14ArURkspqFHZW2jKGd-YrMwX6PU-d5g2HdRVNo2utUP0nYt3Njhv_z3p_c5uwzebQyRVIge8PATE8HWCNNrOp1nT9RCmZJlSRmum868u0PP_0JswxT7rWWZ4kYW4EX-orWvB-r4J-d5qDrVnQmYLytT8brKnqhhSitAcn8yoncu3uXw7l2_n8jP_7G_PI_277Qy82ANpcH3t65COTE4ijBMqCBe05D8BWMO1bQ</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>KHOO, BOON-YIN</creator><creator>NADARAJAN, KALPANAH</creator><creator>SHIM, SIANG-YIAN</creator><creator>MISWAN, NOORIZAN</creator><creator>ZANG, CHUAN-BING</creator><creator>POSSINGER, KURT</creator><creator>ELSTNER, ELENA</creator><general>D.A. 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cytology</topic><topic>bone marrow-derived mesenchymal stem cells</topic><topic>Breast cancer</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells, Cultured</topic><topic>Chemokines - genetics</topic><topic>Chemokines - metabolism</topic><topic>Coculture Techniques</topic><topic>Culture Media, Conditioned - pharmacology</topic><topic>Cytokines - genetics</topic><topic>Cytokines - metabolism</topic><topic>Down-Regulation - drug effects</topic><topic>FGF4</topic><topic>Fibroblast growth factor 4</topic><topic>Fibroblast Growth Factor 4 - genetics</topic><topic>Fibroblast Growth Factor 4 - metabolism</topic><topic>Fibroblast growth factors</topic><topic>Fibroblasts</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glucose</topic><topic>Growth</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Ki-67 Antigen - metabolism</topic><topic>Laboratories</topic><topic>MCF-7</topic><topic>MCF-7 Cells</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - drug effects</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mesenchyme</topic><topic>Metastasis</topic><topic>Morphology</topic><topic>Observations</topic><topic>Penicillin</topic><topic>Pioglitazone</topic><topic>Prescription drugs</topic><topic>Proliferating cell nuclear antigen</topic><topic>Proliferating Cell Nuclear Antigen - metabolism</topic><topic>proliferation rate</topic><topic>Properties</topic><topic>Proteins</topic><topic>Rosiglitazone</topic><topic>Stem cells</topic><topic>stem- and -cancer cell interaction</topic><topic>Studies</topic><topic>Thiazolidinediones</topic><topic>Thiazolidinediones - pharmacology</topic><topic>TZD solution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KHOO, BOON-YIN</creatorcontrib><creatorcontrib>NADARAJAN, KALPANAH</creatorcontrib><creatorcontrib>SHIM, SIANG-YIAN</creatorcontrib><creatorcontrib>MISWAN, NOORIZAN</creatorcontrib><creatorcontrib>ZANG, CHUAN-BING</creatorcontrib><creatorcontrib>POSSINGER, KURT</creatorcontrib><creatorcontrib>ELSTNER, ELENA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KHOO, BOON-YIN</au><au>NADARAJAN, KALPANAH</au><au>SHIM, SIANG-YIAN</au><au>MISWAN, NOORIZAN</au><au>ZANG, CHUAN-BING</au><au>POSSINGER, KURT</au><au>ELSTNER, ELENA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF-7 cells by reducing FGF4 protein expression</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>13</volume><issue>4</issue><spage>3406</spage><epage>3414</epage><pages>3406-3414</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>The present study aimed to investigate the effects of bone marrow-derived mesenchymal stem cells (BMSCs) that had been pretreated with pioglitazone and/or rosiglitazone on the growth and proliferation rate of MCF-7 cells. The adhesive interaction between the BMSCs and the MCF-7 cancer cells revealed that the pretreatment of BMSCs with a combination of two types of thiazolidinedione drug reduced the growth and proliferation rate of the MCF-7 cells. The proliferation rate of the MCF-7 cells could also be reduced by the non-adhesive interaction of the cancer cells with BMSCs pretreated with pioglitazone and/or rosiglitazone. The growth and proliferation rate reduction effects on the MCF-7 cells may be attributed to the reduction in the protein level of fibroblast growth factor 4 (FGF4) in the conditioned medium of the pretreated BMSCs. The evidence that the low protein level of FGF4 in the conditioned medium of the pretreated BMSCs perturbed the proliferation rate of the MCF-7 cells by reducing the levels of Ki-67 and proliferating cell nuclear antigen transcripts in the cancer cells was also demonstrated in the present study using a FGF4-neutralizing antibody. All the above findings demonstrate that future studies on the correlation between FGF4 and pretreated BMSCs would be beneficial.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26934829</pmid><doi>10.3892/mmr.2016.4959</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2016-04, Vol.13 (4), p.3406-3414 |
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| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adhesives Bone marrow Bone Marrow Cells - cytology bone marrow-derived mesenchymal stem cells Breast cancer Cancer Cancer therapies Cell growth Cell proliferation Cell Proliferation - drug effects Cells, Cultured Chemokines - genetics Chemokines - metabolism Coculture Techniques Culture Media, Conditioned - pharmacology Cytokines - genetics Cytokines - metabolism Down-Regulation - drug effects FGF4 Fibroblast growth factor 4 Fibroblast Growth Factor 4 - genetics Fibroblast Growth Factor 4 - metabolism Fibroblast growth factors Fibroblasts Gene Expression Regulation - drug effects Glucose Growth Growth factors Humans Ki-67 Antigen - metabolism Laboratories MCF-7 MCF-7 Cells Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mesenchyme Metastasis Morphology Observations Penicillin Pioglitazone Prescription drugs Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism proliferation rate Properties Proteins Rosiglitazone Stem cells stem- and -cancer cell interaction Studies Thiazolidinediones Thiazolidinediones - pharmacology TZD solution |
| title | Pretreatment of BMSCs with TZD solution decreases the proliferation rate of MCF-7 cells by reducing FGF4 protein expression |
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