Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats
In the present study, mesenchymal stem cells (MSCs) were transplanted into the brain of rats following cardiopulmonary resuscitation (CPR) by three different methods: Direct stereotaxic injection into the lateral cerebral ventricle (LV), intra-carotid administration (A), and femoral venous infusion...
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| Veröffentlicht in: | Molecular medicine reports 2016-04, Vol.13 (4), p.3043-3051 |
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| creator | LEONG, KA-HONG ZHOU, LI-LI LIN, QING-MING WANG, PENG YAO, LAN HUANG, ZI-TONG |
| description | In the present study, mesenchymal stem cells (MSCs) were transplanted into the brain of rats following cardiopulmonary resuscitation (CPR) by three different methods: Direct stereotaxic injection into the lateral cerebral ventricle (LV), intra-carotid administration (A), and femoral venous infusion (V). The three different methods were compared by observing the effects of MSCs on neurological function following global cerebral hypoxia-ischemia, in order to determine the optimum method for MSC transplantation. MSCs were transplanted in groups A, V and LV following the restoration of spontaneous circulation. Neurological deficit scale scores were higher in the transplantation groups, as compared with the control group. Neuronal damage, brain water content and serum levels of S100 calcium-binding protein B were reduced in the hippo-campus and temporal cortex of the transplantation groups, as compared with the control rats following resuscitation. MSCs were able to migrate inside the brain tissue following transplantation, and were predominantly distributed in the hippocampus and temporal cortex where the neurons were vulnerable during global cerebral ischemia. These results suggest that transplantation of MSCs may notably improve neurological function following CPR in a rat model. Of the three different methods of MSC transplantation tested in the present study, LV induced the highest concentration of MSCs in brain areas vulnerable to global cerebral ischemia, and therefore, produced the best neurological outcome. |
| doi_str_mv | 10.3892/mmr.2016.4927 |
| format | Article |
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The three different methods were compared by observing the effects of MSCs on neurological function following global cerebral hypoxia-ischemia, in order to determine the optimum method for MSC transplantation. MSCs were transplanted in groups A, V and LV following the restoration of spontaneous circulation. Neurological deficit scale scores were higher in the transplantation groups, as compared with the control group. Neuronal damage, brain water content and serum levels of S100 calcium-binding protein B were reduced in the hippo-campus and temporal cortex of the transplantation groups, as compared with the control rats following resuscitation. MSCs were able to migrate inside the brain tissue following transplantation, and were predominantly distributed in the hippocampus and temporal cortex where the neurons were vulnerable during global cerebral ischemia. These results suggest that transplantation of MSCs may notably improve neurological function following CPR in a rat model. Of the three different methods of MSC transplantation tested in the present study, LV induced the highest concentration of MSCs in brain areas vulnerable to global cerebral ischemia, and therefore, produced the best neurological outcome.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2016.4927</identifier><identifier>PMID: 26935023</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Animals ; Biomarkers ; Blood Pressure ; Blood-brain barrier ; Bone marrow ; bone marrow mesenchymal stem cells ; Brain damage ; Brain injury ; Calcium-binding protein ; Cardiac arrest ; Care and treatment ; Cell Culture Techniques ; Cell Movement ; Cell Separation ; Cell Tracking ; Cerebral blood flow ; Cerebral ischemia ; cerebral resuscitation ; Cortex (temporal) ; CPR (First aid) ; Disease Models, Animal ; Femur ; global cerebral ischemic injury ; Heart Arrest ; Heart diseases ; Heart Rate ; Hippocampus - metabolism ; Hippocampus - pathology ; Humidity ; Hypoxia ; Immunophenotyping ; Ischemia ; Laboratory animals ; Male ; Mesenchymal Stem Cell Transplantation ; Mesenchymal stem cells ; Mesenchymal Stromal Cells - cytology ; Mesenchymal Stromal Cells - metabolism ; Mesenchyme ; Mortality ; Physiological aspects ; Protein B ; Proteins ; Rats ; Resuscitation - methods ; Rodents ; Serum levels ; Standard deviation ; Stem cell transplantation ; Stem cells ; Studies ; Temporal Lobe - metabolism ; Temporal Lobe - pathology ; Transplantation ; Ventricle ; Ventricles (cerebral) ; Water content</subject><ispartof>Molecular medicine reports, 2016-04, Vol.13 (4), p.3043-3051</ispartof><rights>Copyright: © Leong et al.</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright: © Leong et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-7e88895155de936a8f2819433eec557ae2664b32dd61f0da938dbd862a4a117b3</citedby><cites>FETCH-LOGICAL-c580t-7e88895155de936a8f2819433eec557ae2664b32dd61f0da938dbd862a4a117b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,5571,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26935023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEONG, KA-HONG</creatorcontrib><creatorcontrib>ZHOU, LI-LI</creatorcontrib><creatorcontrib>LIN, QING-MING</creatorcontrib><creatorcontrib>WANG, PENG</creatorcontrib><creatorcontrib>YAO, LAN</creatorcontrib><creatorcontrib>HUANG, ZI-TONG</creatorcontrib><title>Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>In the present study, mesenchymal stem cells (MSCs) were transplanted into the brain of rats following cardiopulmonary resuscitation (CPR) by three different methods: Direct stereotaxic injection into the lateral cerebral ventricle (LV), intra-carotid administration (A), and femoral venous infusion (V). The three different methods were compared by observing the effects of MSCs on neurological function following global cerebral hypoxia-ischemia, in order to determine the optimum method for MSC transplantation. MSCs were transplanted in groups A, V and LV following the restoration of spontaneous circulation. Neurological deficit scale scores were higher in the transplantation groups, as compared with the control group. Neuronal damage, brain water content and serum levels of S100 calcium-binding protein B were reduced in the hippo-campus and temporal cortex of the transplantation groups, as compared with the control rats following resuscitation. MSCs were able to migrate inside the brain tissue following transplantation, and were predominantly distributed in the hippocampus and temporal cortex where the neurons were vulnerable during global cerebral ischemia. These results suggest that transplantation of MSCs may notably improve neurological function following CPR in a rat model. Of the three different methods of MSC transplantation tested in the present study, LV induced the highest concentration of MSCs in brain areas vulnerable to global cerebral ischemia, and therefore, produced the best neurological outcome.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Blood Pressure</subject><subject>Blood-brain barrier</subject><subject>Bone marrow</subject><subject>bone marrow mesenchymal stem cells</subject><subject>Brain damage</subject><subject>Brain injury</subject><subject>Calcium-binding protein</subject><subject>Cardiac arrest</subject><subject>Care and treatment</subject><subject>Cell Culture Techniques</subject><subject>Cell Movement</subject><subject>Cell Separation</subject><subject>Cell Tracking</subject><subject>Cerebral blood flow</subject><subject>Cerebral ischemia</subject><subject>cerebral resuscitation</subject><subject>Cortex (temporal)</subject><subject>CPR (First aid)</subject><subject>Disease Models, Animal</subject><subject>Femur</subject><subject>global cerebral ischemic injury</subject><subject>Heart Arrest</subject><subject>Heart diseases</subject><subject>Heart Rate</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Humidity</subject><subject>Hypoxia</subject><subject>Immunophenotyping</subject><subject>Ischemia</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Mesenchymal Stem Cell Transplantation</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Mesenchyme</subject><subject>Mortality</subject><subject>Physiological aspects</subject><subject>Protein B</subject><subject>Proteins</subject><subject>Rats</subject><subject>Resuscitation - methods</subject><subject>Rodents</subject><subject>Serum levels</subject><subject>Standard deviation</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Temporal Lobe - metabolism</subject><subject>Temporal Lobe - pathology</subject><subject>Transplantation</subject><subject>Ventricle</subject><subject>Ventricles (cerebral)</subject><subject>Water content</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkk2PFCEQhjtG466rR6-GxINeeuSjoeFispn4lazx4HomNFTPsOmGFrpX_ffSzji6xkACqXrqJVW8VfWU4A2Tir4ax7ShmIhNo2h7rzonrSI1w7i5f7xTpdqz6lHONxgLTrl6WJ1RoRjHlJ1X36_3kMwEy-wtgr4HO2cUe3Rrko9LRiPM--h-hT5-3qI5mZCnwYTZzD4GVLaFBF0yA0qQl2z9MdPHYYjffNgha5LzxiKTCjEjH1Ayc35cPejNkOHJ8byovrx9c719X199evdhe3lVWy7xXLcgpVSccO5AMWFkTyVRDWMAlvPWABWi6Rh1TpAeO6OYdJ2TgprGENJ27KJ6fdCdlm4EZyGUHgY9JT-a9ENH4_XdTPB7vYu3upGYY9EWgZdHgRS_LqUDPfpsYShDgDIhTdpWSYkFkwV9_g96E5cUSnuaKEabtizxh9qZAbQPfSzv2lVUXzZcco4JXanNf6iyHIzexgC9L_E7BfWhwKaYc4L-1CPBerWKLlbRq1X0apXCP_t7MCf6tzcK8OIA5MkE513MJ6Yo1YTVuClOK3_xE4ziyB4</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>LEONG, KA-HONG</creator><creator>ZHOU, LI-LI</creator><creator>LIN, QING-MING</creator><creator>WANG, PENG</creator><creator>YAO, LAN</creator><creator>HUANG, ZI-TONG</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160401</creationdate><title>Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats</title><author>LEONG, KA-HONG ; ZHOU, LI-LI ; LIN, QING-MING ; WANG, PENG ; YAO, LAN ; HUANG, ZI-TONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-7e88895155de936a8f2819433eec557ae2664b32dd61f0da938dbd862a4a117b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Blood Pressure</topic><topic>Blood-brain barrier</topic><topic>Bone marrow</topic><topic>bone marrow mesenchymal stem cells</topic><topic>Brain damage</topic><topic>Brain injury</topic><topic>Calcium-binding protein</topic><topic>Cardiac arrest</topic><topic>Care and treatment</topic><topic>Cell Culture Techniques</topic><topic>Cell Movement</topic><topic>Cell Separation</topic><topic>Cell Tracking</topic><topic>Cerebral blood flow</topic><topic>Cerebral ischemia</topic><topic>cerebral resuscitation</topic><topic>Cortex (temporal)</topic><topic>CPR (First aid)</topic><topic>Disease Models, Animal</topic><topic>Femur</topic><topic>global cerebral ischemic injury</topic><topic>Heart Arrest</topic><topic>Heart diseases</topic><topic>Heart Rate</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Humidity</topic><topic>Hypoxia</topic><topic>Immunophenotyping</topic><topic>Ischemia</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Mesenchymal Stem Cell Transplantation</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Mesenchyme</topic><topic>Mortality</topic><topic>Physiological aspects</topic><topic>Protein B</topic><topic>Proteins</topic><topic>Rats</topic><topic>Resuscitation - methods</topic><topic>Rodents</topic><topic>Serum levels</topic><topic>Standard deviation</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Studies</topic><topic>Temporal Lobe - metabolism</topic><topic>Temporal Lobe - pathology</topic><topic>Transplantation</topic><topic>Ventricle</topic><topic>Ventricles (cerebral)</topic><topic>Water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEONG, KA-HONG</creatorcontrib><creatorcontrib>ZHOU, LI-LI</creatorcontrib><creatorcontrib>LIN, QING-MING</creatorcontrib><creatorcontrib>WANG, PENG</creatorcontrib><creatorcontrib>YAO, LAN</creatorcontrib><creatorcontrib>HUANG, ZI-TONG</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEONG, KA-HONG</au><au>ZHOU, LI-LI</au><au>LIN, QING-MING</au><au>WANG, PENG</au><au>YAO, LAN</au><au>HUANG, ZI-TONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>13</volume><issue>4</issue><spage>3043</spage><epage>3051</epage><pages>3043-3051</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>In the present study, mesenchymal stem cells (MSCs) were transplanted into the brain of rats following cardiopulmonary resuscitation (CPR) by three different methods: Direct stereotaxic injection into the lateral cerebral ventricle (LV), intra-carotid administration (A), and femoral venous infusion (V). The three different methods were compared by observing the effects of MSCs on neurological function following global cerebral hypoxia-ischemia, in order to determine the optimum method for MSC transplantation. MSCs were transplanted in groups A, V and LV following the restoration of spontaneous circulation. Neurological deficit scale scores were higher in the transplantation groups, as compared with the control group. Neuronal damage, brain water content and serum levels of S100 calcium-binding protein B were reduced in the hippo-campus and temporal cortex of the transplantation groups, as compared with the control rats following resuscitation. MSCs were able to migrate inside the brain tissue following transplantation, and were predominantly distributed in the hippocampus and temporal cortex where the neurons were vulnerable during global cerebral ischemia. These results suggest that transplantation of MSCs may notably improve neurological function following CPR in a rat model. Of the three different methods of MSC transplantation tested in the present study, LV induced the highest concentration of MSCs in brain areas vulnerable to global cerebral ischemia, and therefore, produced the best neurological outcome.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>26935023</pmid><doi>10.3892/mmr.2016.4927</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2016-04, Vol.13 (4), p.3043-3051 |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biomarkers Blood Pressure Blood-brain barrier Bone marrow bone marrow mesenchymal stem cells Brain damage Brain injury Calcium-binding protein Cardiac arrest Care and treatment Cell Culture Techniques Cell Movement Cell Separation Cell Tracking Cerebral blood flow Cerebral ischemia cerebral resuscitation Cortex (temporal) CPR (First aid) Disease Models, Animal Femur global cerebral ischemic injury Heart Arrest Heart diseases Heart Rate Hippocampus - metabolism Hippocampus - pathology Humidity Hypoxia Immunophenotyping Ischemia Laboratory animals Male Mesenchymal Stem Cell Transplantation Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mesenchyme Mortality Physiological aspects Protein B Proteins Rats Resuscitation - methods Rodents Serum levels Standard deviation Stem cell transplantation Stem cells Studies Temporal Lobe - metabolism Temporal Lobe - pathology Transplantation Ventricle Ventricles (cerebral) Water content |
| title | Therapeutic effects of various methods of MSC transplantation on cerebral resuscitation following cardiac arrest in rats |
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