Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new antischistosomal drugs

Investigations on the chemistry and mechanism of action of 2-methyl-1,4-naphthoquinone (or menadione) derivatives, revealed 3-phenoxymethyl menadiones as a novel antischistosomal series. These newly synthesized compounds 1–7 and their difluoromethylmenadione counterparts 8–9 were found to be potent...

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Veröffentlicht in:	The FEBS journal 2015-08, Vol.282 (16), p.3199-3217
Hauptverfasser:	Johann, Laure, Belorgey, Didier, Huang, Hsin-Hung, Day, Latasha, Chessé, Matthieu, Becker, Katja, Williams, David L., Davioud-Charvet, Elisabeth
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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