Adjustment disorder and risk of Parkinson's disease
Background and purpose It has been postulated that stress is part of the etiological process of Parkinson's disease (PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event. Methods Using...
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| Veröffentlicht in: | European journal of neurology 2016-04, Vol.23 (4), p.751-756 |
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| container_title | European journal of neurology |
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| creator | Svensson, E. Farkas, D. K. Gradus, J. L. Lash, T. L. Sørensen, H. T. |
| description | Background and purpose
It has been postulated that stress is part of the etiological process of Parkinson's disease (PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event.
Methods
Using Danish medical registries, PD occurrence was examined in a nationwide population‐based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety.
Results
Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow‐up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety.
Conclusion
Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD. |
| doi_str_mv | 10.1111/ene.12933 |
| format | Article |
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It has been postulated that stress is part of the etiological process of Parkinson's disease (PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event.
Methods
Using Danish medical registries, PD occurrence was examined in a nationwide population‐based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety.
Results
Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow‐up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety.
Conclusion
Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD.</description><identifier>ISSN: 1351-5101</identifier><identifier>EISSN: 1468-1331</identifier><identifier>DOI: 10.1111/ene.12933</identifier><identifier>PMID: 26756302</identifier><identifier>CODEN: EJNEFL</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>adjustment disorder ; Adjustment Disorders - epidemiology ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Comorbidity ; Confidence intervals ; Denmark ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Parkinson Disease - epidemiology ; Parkinson's disease ; psychological stress ; Registries ; Risk ; Young Adult</subject><ispartof>European journal of neurology, 2016-04, Vol.23 (4), p.751-756</ispartof><rights>2016 EAN</rights><rights>2016 EAN.</rights><rights>European Journal of Neurology © 2016 European Academy of Neurology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5473-9c75ad2d40a453f904d8c8161ff44165e2fac28c07a673a209a47913b593bf7e3</citedby><cites>FETCH-LOGICAL-c5473-9c75ad2d40a453f904d8c8161ff44165e2fac28c07a673a209a47913b593bf7e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fene.12933$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fene.12933$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26756302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Svensson, E.</creatorcontrib><creatorcontrib>Farkas, D. K.</creatorcontrib><creatorcontrib>Gradus, J. L.</creatorcontrib><creatorcontrib>Lash, T. L.</creatorcontrib><creatorcontrib>Sørensen, H. T.</creatorcontrib><title>Adjustment disorder and risk of Parkinson's disease</title><title>European journal of neurology</title><addtitle>Eur J Neurol</addtitle><description>Background and purpose
It has been postulated that stress is part of the etiological process of Parkinson's disease (PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event.
Methods
Using Danish medical registries, PD occurrence was examined in a nationwide population‐based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety.
Results
Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow‐up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety.
Conclusion
Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD.</description><subject>adjustment disorder</subject><subject>Adjustment Disorders - epidemiology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Comorbidity</subject><subject>Confidence intervals</subject><subject>Denmark</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>psychological stress</subject><subject>Registries</subject><subject>Risk</subject><subject>Young Adult</subject><issn>1351-5101</issn><issn>1468-1331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFPGzEQhS0EaoD20D-AVuJAe1gYe-z17gUpilICCikHEEfL2fW2TjZrsLOl_Ps6BCKKhIQvY2m-eZp5j5CvFI5pfCemNceUFYhbZJfyLE8pIt2OfxQ0FRRoj-yFMAMAJhl8Ij2WSZEhsF2C_WrWheXCtMukssH5yvhEt1XibZgnrk6utJ_bNrj2KKwAo4P5THZq3QTz5bnuk5sfw-vBKB3_PDsf9MdpKbjEtCil0BWrOGgusC6AV3mZ04zWNec0E4bVumR5CVJnEjWDQnNZUJyKAqe1NLhPTte6d910Yaoy7uh1o-68XWj_qJy26v9Oa3-rX-6P4jmgyPMo8O1ZwLv7zoSlWthQmqbRrXFdUFTmIACExA-gUqCUBc8ievgGnbnOt9GJFRXtB8pEpL6vqdK7ELypN3tTUKvUVExNPaUW2YPXh27Il5gicLIGHmxjHt9XUsPJ8EUyXU_YsDR_NxMxTBXNlkLdTs7UxWR8PZLsUo3wH5jErj8</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Svensson, E.</creator><creator>Farkas, D. K.</creator><creator>Gradus, J. L.</creator><creator>Lash, T. L.</creator><creator>Sørensen, H. T.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>Adjustment disorder and risk of Parkinson's disease</title><author>Svensson, E. ; Farkas, D. K. ; Gradus, J. L. ; Lash, T. L. ; Sørensen, H. T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5473-9c75ad2d40a453f904d8c8161ff44165e2fac28c07a673a209a47913b593bf7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>adjustment disorder</topic><topic>Adjustment Disorders - epidemiology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Comorbidity</topic><topic>Confidence intervals</topic><topic>Denmark</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>psychological stress</topic><topic>Registries</topic><topic>Risk</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Svensson, E.</creatorcontrib><creatorcontrib>Farkas, D. K.</creatorcontrib><creatorcontrib>Gradus, J. L.</creatorcontrib><creatorcontrib>Lash, T. L.</creatorcontrib><creatorcontrib>Sørensen, H. T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Svensson, E.</au><au>Farkas, D. K.</au><au>Gradus, J. L.</au><au>Lash, T. L.</au><au>Sørensen, H. T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adjustment disorder and risk of Parkinson's disease</atitle><jtitle>European journal of neurology</jtitle><addtitle>Eur J Neurol</addtitle><date>2016-04</date><risdate>2016</risdate><volume>23</volume><issue>4</issue><spage>751</spage><epage>756</epage><pages>751-756</pages><issn>1351-5101</issn><eissn>1468-1331</eissn><coden>EJNEFL</coden><abstract>Background and purpose
It has been postulated that stress is part of the etiological process of Parkinson's disease (PD). The risk of PD was examined in a cohort of patients with adjustment disorders, a diagnosis made in the presence of a severe response to a stressful life event.
Methods
Using Danish medical registries, PD occurrence was examined in a nationwide population‐based cohort of patients with adjustment disorder diagnosed between 1995 and 2011. The standardized incidence ratio of PD was calculated as the ratio of observed to expected cases, stratified by time and potential risk factors, including depression and anxiety.
Results
Our adjustment disorder cohort (67 786 patients) was followed for a median of 8 years (interquartile range 4, 12.6 years). During follow‐up, 119 patients developed PD, versus 64 expected, corresponding to a standardized incidence ratio of 1.84 (95% confidence interval 1.53, 2.20). Consistent results were observed after stratification on potential risk factors, including depression and anxiety.
Conclusion
Adjustment disorder, a diagnosis made in the presence of severe response to stressful life events, was associated with an increased risk of PD.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26756302</pmid><doi>10.1111/ene.12933</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adjustment disorder Adjustment Disorders - epidemiology Adolescent Adult Aged Aged, 80 and over Comorbidity Confidence intervals Denmark Female Follow-Up Studies Humans Male Middle Aged Parkinson Disease - epidemiology Parkinson's disease psychological stress Registries Risk Young Adult |
| title | Adjustment disorder and risk of Parkinson's disease |
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