Reducing Dose Uncertainty for Spot-Scanning Proton Beam Therapy of Moving Tumors by Optimizing the Spot Delivery Sequence

Purpose To develop and validate a novel delivery strategy for reducing the respiratory motion–induced dose uncertainty of spot-scanning proton therapy. Methods and Materials The spot delivery sequence was optimized to reduce dose uncertainty. The effectiveness of the delivery sequence optimization w...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-11, Vol.93 (3), p.547-556
Hauptverfasser:	Li, Heng, PhD, Zhu, X. Ronald, PhD, Zhang, Xiaodong, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Graphics DELIVERY ERRORS Hematology, Oncology and Palliative Medicine Humans Lung Neoplasms - diagnostic imaging Lung Neoplasms - radiotherapy Movement NEOPLASMS OPTIMIZATION PATIENTS PROTON BEAMS Proton Therapy - methods RADIATION DOSES Radiography Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - methods Respiration Retrospective Studies SIMULATION Uncertainty
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