Environmental exposure to manganese in air: Associations with cognitive functions
•186 adult residents of two towns environmentally exposed to manganese in air.•Modeled mean average air-Mn exposures over 10 years range from 0.01 to 6.32μg/m3.•Cognitive function was assessed with comprehensive neuropsychological screening test battery.•Increased air-Mn levels inversely related to...
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| Veröffentlicht in: | Neurotoxicology (Park Forest South) 2015-07, Vol.49, p.139-148 |
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| creator | Bowler, Rosemarie M. Kornblith, Erica S. Gocheva, Vihra V. Colledge, Michelle A. Bollweg, George Kim, Yangho Beseler, Cheryl L. Wright, Chris W. Adams, Shane W. Lobdell, Danelle T. |
| description | •186 adult residents of two towns environmentally exposed to manganese in air.•Modeled mean average air-Mn exposures over 10 years range from 0.01 to 6.32μg/m3.•Cognitive function was assessed with comprehensive neuropsychological screening test battery.•Increased air-Mn levels inversely related to working/visuospatial memory and verbal skills.
Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources.
Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61μg/m3 in Marietta and 0.01–6.32μg/m3 in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (±10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p |
| doi_str_mv | 10.1016/j.neuro.2015.06.004 |
| format | Article |
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Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources.
Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61μg/m3 in Marietta and 0.01–6.32μg/m3 in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (±10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p<0.05) were found between Mn exposure and performance on working and visuospatial memory (e.g., Rey-O Immediate β=−0.19, Rey-O Delayed β=−0.16) and verbal skills (e.g., Similarities β=−0.19).
Using extensive cognitive testing and computer modeling of 10-plus years of measured air monitoring data, this study suggests that long-term environmental exposure to high levels of air-Mn, the exposure metric of this paper, may result in mild deficits of cognitive function in adult populations.</description><identifier>ISSN: 0161-813X</identifier><identifier>EISSN: 1872-9711</identifier><identifier>DOI: 10.1016/j.neuro.2015.06.004</identifier><identifier>PMID: 26096496</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Air ; Air Pollution - adverse effects ; Cognition - physiology ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognitive function ; Cross-Sectional Studies ; Environmental ; Environmental Exposure ; Female ; Humans ; Longitudinal Studies ; Male ; Manganese ; Manganese - adverse effects ; Middle Aged ; Neuropsychological Tests ; Neuropsychology ; Statistics, Nonparametric</subject><ispartof>Neurotoxicology (Park Forest South), 2015-07, Vol.49, p.139-148</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-fbcbdb9f78568f367a5dd2d9b4127330f278e43594646b8eefbacf6c39482f6d3</citedby><cites>FETCH-LOGICAL-c492t-fbcbdb9f78568f367a5dd2d9b4127330f278e43594646b8eefbacf6c39482f6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuro.2015.06.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26096496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowler, Rosemarie M.</creatorcontrib><creatorcontrib>Kornblith, Erica S.</creatorcontrib><creatorcontrib>Gocheva, Vihra V.</creatorcontrib><creatorcontrib>Colledge, Michelle A.</creatorcontrib><creatorcontrib>Bollweg, George</creatorcontrib><creatorcontrib>Kim, Yangho</creatorcontrib><creatorcontrib>Beseler, Cheryl L.</creatorcontrib><creatorcontrib>Wright, Chris W.</creatorcontrib><creatorcontrib>Adams, Shane W.</creatorcontrib><creatorcontrib>Lobdell, Danelle T.</creatorcontrib><title>Environmental exposure to manganese in air: Associations with cognitive functions</title><title>Neurotoxicology (Park Forest South)</title><addtitle>Neurotoxicology</addtitle><description>•186 adult residents of two towns environmentally exposed to manganese in air.•Modeled mean average air-Mn exposures over 10 years range from 0.01 to 6.32μg/m3.•Cognitive function was assessed with comprehensive neuropsychological screening test battery.•Increased air-Mn levels inversely related to working/visuospatial memory and verbal skills.
Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources.
Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61μg/m3 in Marietta and 0.01–6.32μg/m3 in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (±10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p<0.05) were found between Mn exposure and performance on working and visuospatial memory (e.g., Rey-O Immediate β=−0.19, Rey-O Delayed β=−0.16) and verbal skills (e.g., Similarities β=−0.19).
Using extensive cognitive testing and computer modeling of 10-plus years of measured air monitoring data, this study suggests that long-term environmental exposure to high levels of air-Mn, the exposure metric of this paper, may result in mild deficits of cognitive function in adult populations.</description><subject>Adult</subject><subject>Aged</subject><subject>Air</subject><subject>Air Pollution - adverse effects</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive function</subject><subject>Cross-Sectional Studies</subject><subject>Environmental</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Manganese</subject><subject>Manganese - adverse effects</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Statistics, Nonparametric</subject><issn>0161-813X</issn><issn>1872-9711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1rFTEUhoMo9lr9BYLM0s2M-Zp8CAql1A8oiKDgLmQyJ7e5zCTXZOZW_71pby26EVdZnOe8yZsHoecEdwQT8WrXRVhz6igmfYdFhzF_gDZESdpqSchDtKkUaRVh307Qk1J2uIJS6MfohAqsBddigz5fxEPIKc4QFzs18GOfypqhWVIz27i1EQo0ITY25NfNWSnJBbuEFEtzHZarxqVtDEs4QOPX6G4HT9Ejb6cCz-7OU_T13cWX8w_t5af3H8_PLlvHNV1aP7hhHLSXqhfKMyFtP4501AMnVDKGPZUKOOs1F1wMCsAP1nnhmOaKejGyU_T2mLtfhxlGVwtkO5l9DrPNP02ywfw9ieHKbNPBcIUZVaoGvLwLyOn7CmUxcygOpqmWTmsxROIeK0F7-T8oYRwzKSrKjqjLqZQM_v5FBJsbb2Znbr2ZG28GC1O91a0Xf5a53_ktqgJvjgDULz0EyKa4ANHBGDK4xYwp_POCX8FYrR8</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Bowler, Rosemarie M.</creator><creator>Kornblith, Erica S.</creator><creator>Gocheva, Vihra V.</creator><creator>Colledge, Michelle A.</creator><creator>Bollweg, George</creator><creator>Kim, Yangho</creator><creator>Beseler, Cheryl L.</creator><creator>Wright, Chris W.</creator><creator>Adams, Shane W.</creator><creator>Lobdell, Danelle T.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7TK</scope><scope>7TV</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>5PM</scope></search><sort><creationdate>20150701</creationdate><title>Environmental exposure to manganese in air: Associations with cognitive functions</title><author>Bowler, Rosemarie M. ; Kornblith, Erica S. ; Gocheva, Vihra V. ; Colledge, Michelle A. ; Bollweg, George ; Kim, Yangho ; Beseler, Cheryl L. ; Wright, Chris W. ; Adams, Shane W. ; Lobdell, Danelle T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-fbcbdb9f78568f367a5dd2d9b4127330f278e43594646b8eefbacf6c39482f6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Air</topic><topic>Air Pollution - adverse effects</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive function</topic><topic>Cross-Sectional Studies</topic><topic>Environmental</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Manganese</topic><topic>Manganese - adverse effects</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowler, Rosemarie M.</creatorcontrib><creatorcontrib>Kornblith, Erica S.</creatorcontrib><creatorcontrib>Gocheva, Vihra V.</creatorcontrib><creatorcontrib>Colledge, Michelle A.</creatorcontrib><creatorcontrib>Bollweg, George</creatorcontrib><creatorcontrib>Kim, Yangho</creatorcontrib><creatorcontrib>Beseler, Cheryl L.</creatorcontrib><creatorcontrib>Wright, Chris W.</creatorcontrib><creatorcontrib>Adams, Shane W.</creatorcontrib><creatorcontrib>Lobdell, Danelle T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurotoxicology (Park Forest South)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowler, Rosemarie M.</au><au>Kornblith, Erica S.</au><au>Gocheva, Vihra V.</au><au>Colledge, Michelle A.</au><au>Bollweg, George</au><au>Kim, Yangho</au><au>Beseler, Cheryl L.</au><au>Wright, Chris W.</au><au>Adams, Shane W.</au><au>Lobdell, Danelle T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental exposure to manganese in air: Associations with cognitive functions</atitle><jtitle>Neurotoxicology (Park Forest South)</jtitle><addtitle>Neurotoxicology</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>49</volume><spage>139</spage><epage>148</epage><pages>139-148</pages><issn>0161-813X</issn><eissn>1872-9711</eissn><abstract>•186 adult residents of two towns environmentally exposed to manganese in air.•Modeled mean average air-Mn exposures over 10 years range from 0.01 to 6.32μg/m3.•Cognitive function was assessed with comprehensive neuropsychological screening test battery.•Increased air-Mn levels inversely related to working/visuospatial memory and verbal skills.
Manganese (Mn), an essential element, can be neurotoxic in high doses. This cross-sectional study explored the cognitive function of adults residing in two towns (Marietta and East Liverpool, Ohio, USA) identified as having high levels of environmental airborne Mn from industrial sources.
Air-Mn site surface emissions method modeling for total suspended particulate (TSP) ranged from 0.03 to 1.61μg/m3 in Marietta and 0.01–6.32μg/m3 in East Liverpool. A comprehensive screening test battery of cognitive function, including the domains of abstract thinking, attention/concentration, executive function and memory was administered. The mean age of the participants was 56 years (±10.8 years). Participants were mostly female (59.1) and primarily white (94.6%). Significant relationships (p<0.05) were found between Mn exposure and performance on working and visuospatial memory (e.g., Rey-O Immediate β=−0.19, Rey-O Delayed β=−0.16) and verbal skills (e.g., Similarities β=−0.19).
Using extensive cognitive testing and computer modeling of 10-plus years of measured air monitoring data, this study suggests that long-term environmental exposure to high levels of air-Mn, the exposure metric of this paper, may result in mild deficits of cognitive function in adult populations.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26096496</pmid><doi>10.1016/j.neuro.2015.06.004</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neurotoxicology (Park Forest South), 2015-07, Vol.49, p.139-148 |
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| subjects | Adult Aged Air Air Pollution - adverse effects Cognition - physiology Cognition Disorders - epidemiology Cognition Disorders - etiology Cognitive function Cross-Sectional Studies Environmental Environmental Exposure Female Humans Longitudinal Studies Male Manganese Manganese - adverse effects Middle Aged Neuropsychological Tests Neuropsychology Statistics, Nonparametric |
| title | Environmental exposure to manganese in air: Associations with cognitive functions |
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