Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Parkinson’s disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of PD. PARK2 encodes an E3 ubiquitin ligase, Parkin, that can selectively translocate to dysfunctional mitochondria to promote their rem...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2015-07, Vol.87 (2), p.371-381
Hauptverfasser:	Pickrell, Alicia M., Huang, Chiu-Hui, Kennedy, Scott R., Ordureau, Alban, Sideris, Dionisia P., Hoekstra, Jake G., Harper, J. Wade, Youle, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals DNA, Mitochondrial - genetics Dopamine Plasma Membrane Transport Proteins - metabolism Dopaminergic Neurons - drug effects Dopaminergic Neurons - pathology Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism In Vitro Techniques Levodopa - therapeutic use Mice Mice, Inbred C57BL Mice, Transgenic Mitochondrial Diseases - genetics Mitochondrial Diseases - pathology Mitochondrial DNA Multienzyme Complexes - metabolism Mutation - genetics Neurons Parkinson's disease Proteomics Rodents Substantia Nigra - drug effects Substantia Nigra - pathology Tyrosine 3-Monooxygenase - metabolism Ubiquitin Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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