Efforts to make and apply humanized yeast
Despite a billion years of divergent evolution, the baker's yeast Saccharomyces cerevisiae has long proven to be an invaluable model organism for studying human biology. Given its tractability and ease of genetic manipulation, along with extensive genetic conservation with humans, it is perhaps...
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| Veröffentlicht in: | Briefings in functional genomics 2016-03, Vol.15 (2), p.155-163 |
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| creator | Laurent, Jon M Young, Jonathan H Kachroo, Aashiq H Marcotte, Edward M |
| description | Despite a billion years of divergent evolution, the baker's yeast Saccharomyces cerevisiae has long proven to be an invaluable model organism for studying human biology. Given its tractability and ease of genetic manipulation, along with extensive genetic conservation with humans, it is perhaps no surprise that researchers have been able to expand its utility by expressing human proteins in yeast, or by humanizing specific yeast amino acids, proteins or even entire pathways. These methods are increasingly being scaled in throughput, further enabling the detailed investigation of human biology and disease-specific variations of human genes in a simplified model organism. |
| doi_str_mv | 10.1093/bfgp/elv041 |
| format | Article |
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| ispartof | Briefings in functional genomics, 2016-03, Vol.15 (2), p.155-163 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection |
| subjects | Disease - genetics Drug Discovery Genes, Fungal Genomics Humans Models, Biological Proteins - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism |
| title | Efforts to make and apply humanized yeast |
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