Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility

Periodontitis is a chronic inflammatory disease induced by a biofilm that forms on the tooth surface. Increased periodontal disease is associated with aging. We investigated the effect of aging on challenge by oral pathogens, examining the host response, colonization, and osteoclast numbers in aged...

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Veröffentlicht in:	Journal of dental research 2016-04, Vol.95 (4), p.460-466
Hauptverfasser:	Wu, Y., Dong, G., Xiao, W., Xiao, E., Miao, F., Syverson, A., Missaghian, N., Vafa, R., Cabrera-Ortega, A.A., Rossa, C., Graves, D.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Advanced glycosylation end products Aging Aging - immunology Animals Antigens Bacteria Biofilms Cell Movement Clonal deletion Colonization Data analysis Dendritic cells Dendritic Cells - metabolism Disease Disease Susceptibility Enzyme-Linked Immunosorbent Assay Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Fusobacterium nucleatum - immunology Glycosylation Gum disease Immunohistochemistry Inflammatory diseases Inoculation Interleukin 12 Interleukin-12 - metabolism Laboratories Lymph nodes Lymph Nodes - metabolism Lymphatic system Mice Osteoclasts - metabolism Periodontal diseases Periodontitis Periodontitis - immunology Periodontitis - microbiology Periodontium Plasma cells Porphyromonas gingivalis - immunology Real-Time Polymerase Chain Reaction Research Reports Software Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF X-Ray Microtomography
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