Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis
This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve H. pylori eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining p...
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| Veröffentlicht in: | Scientific reports 2016-03, Vol.6 (1), p.23522-23522, Article 23522 |
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| creator | Lu, Chao Sang, Jianzhong He, Haijian Wan, Xingyong Lin, Yiming Li, Lan Li, Youming Yu, Chaohui |
| description | This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve
H. pylori
eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of
H. pylori
infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of
H. pylori
infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone (
P
= 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of
H. pylori
infection compared to the placebo. |
| doi_str_mv | 10.1038/srep23522 |
| format | Article |
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H. pylori
eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of
H. pylori
infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of
H. pylori
infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone (
P
= 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of
H. pylori
infection compared to the placebo.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep23522</identifier><identifier>PMID: 26997149</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4020/1503/1828/1500 ; 692/699/1503/1828 ; Adult ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Diarrhea ; Dietary Supplements ; Eradication ; Female ; Health risk assessment ; Helicobacter Infections - diet therapy ; Helicobacter pylori - pathogenicity ; Humanities and Social Sciences ; Humans ; Infections ; Male ; Meta-analysis ; Middle Aged ; multidisciplinary ; Nausea ; Placebo Effect ; Placebos ; Probiotics ; Probiotics - adverse effects ; Probiotics - therapeutic use ; Randomized Controlled Trials as Topic ; Science ; Side effects ; Supplements ; Treatment Outcome</subject><ispartof>Scientific reports, 2016-03, Vol.6 (1), p.23522-23522, Article 23522</ispartof><rights>The Author(s) 2016</rights><rights>Copyright Nature Publishing Group Mar 2016</rights><rights>Copyright © 2016, Macmillan Publishers Limited 2016 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-598303687ff51c9786d8cf9828193bcf903794951ab2a534d179b5149b93a4c73</citedby><cites>FETCH-LOGICAL-c438t-598303687ff51c9786d8cf9828193bcf903794951ab2a534d179b5149b93a4c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800733/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800733/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26997149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Chao</creatorcontrib><creatorcontrib>Sang, Jianzhong</creatorcontrib><creatorcontrib>He, Haijian</creatorcontrib><creatorcontrib>Wan, Xingyong</creatorcontrib><creatorcontrib>Lin, Yiming</creatorcontrib><creatorcontrib>Li, Lan</creatorcontrib><creatorcontrib>Li, Youming</creatorcontrib><creatorcontrib>Yu, Chaohui</creatorcontrib><title>Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve
H. pylori
eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of
H. pylori
infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of
H. pylori
infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone (
P
= 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of
H. pylori
infection compared to the placebo.</description><subject>692/4020/1503/1828/1500</subject><subject>692/699/1503/1828</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Diarrhea</subject><subject>Dietary Supplements</subject><subject>Eradication</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Helicobacter Infections - diet therapy</subject><subject>Helicobacter pylori - pathogenicity</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Nausea</subject><subject>Placebo Effect</subject><subject>Placebos</subject><subject>Probiotics</subject><subject>Probiotics - adverse effects</subject><subject>Probiotics - therapeutic use</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Science</subject><subject>Side effects</subject><subject>Supplements</subject><subject>Treatment Outcome</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkd9qFTEQxhdRbKm98AUk4I0Kq_m3J4kXBSnVCgW90Oswm51tU3Y3MckWzrP4sqaeejhqbjLk-_HNTL6mec7oW0aFfpcTRi46zh81x5zKruWC88cH9VFzmvMtrafjRjLztDniG2MUk-a4-fk1hd6H4h3Ja4wTzrgUKD4sZAiYyRIK8XNM4Q4JJhi824kJCpIwkkucvAs9uIKJxO0Ukid-GdH9plyYIyQcSAkkTuCwD6SHXB-qmAssA6Qq3lTnuH1PgMxYoIUFpm32-VnzZIQp4-nDfdJ8_3jx7fyyvfry6fP5h6vWSaFL2xktqNhoNY4dc0bpzaDdaDTXzIi-VlQoI03HoOfQCTkwZfqubt8bAdIpcdKc7Xzj2s84uPoDCSYbk58hbW0Ab_9WFn9jr8OdlZpSJUQ1ePVgkMKPFXOxs88OpwkWDGu2TKlOaKaorOjLf9DbsKa6cKW00Zs6tTGVer2jXAq5Bjzuh2HU3qdu96lX9sXh9HvyT8YVeLMDcpWWa0wHLf9z-wV_brmT</recordid><startdate>20160321</startdate><enddate>20160321</enddate><creator>Lu, Chao</creator><creator>Sang, Jianzhong</creator><creator>He, Haijian</creator><creator>Wan, Xingyong</creator><creator>Lin, Yiming</creator><creator>Li, Lan</creator><creator>Li, Youming</creator><creator>Yu, Chaohui</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160321</creationdate><title>Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis</title><author>Lu, Chao ; Sang, Jianzhong ; He, Haijian ; Wan, Xingyong ; Lin, Yiming ; Li, Lan ; Li, Youming ; Yu, Chaohui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-598303687ff51c9786d8cf9828193bcf903794951ab2a534d179b5149b93a4c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>692/4020/1503/1828/1500</topic><topic>692/699/1503/1828</topic><topic>Adult</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Diarrhea</topic><topic>Dietary Supplements</topic><topic>Eradication</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Helicobacter Infections - diet therapy</topic><topic>Helicobacter pylori - pathogenicity</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Nausea</topic><topic>Placebo Effect</topic><topic>Placebos</topic><topic>Probiotics</topic><topic>Probiotics - adverse effects</topic><topic>Probiotics - therapeutic use</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Science</topic><topic>Side effects</topic><topic>Supplements</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Chao</creatorcontrib><creatorcontrib>Sang, Jianzhong</creatorcontrib><creatorcontrib>He, Haijian</creatorcontrib><creatorcontrib>Wan, Xingyong</creatorcontrib><creatorcontrib>Lin, Yiming</creatorcontrib><creatorcontrib>Li, Lan</creatorcontrib><creatorcontrib>Li, Youming</creatorcontrib><creatorcontrib>Yu, Chaohui</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Chao</au><au>Sang, Jianzhong</au><au>He, Haijian</au><au>Wan, Xingyong</au><au>Lin, Yiming</au><au>Li, Lan</au><au>Li, Youming</au><au>Yu, Chaohui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-03-21</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>23522</spage><epage>23522</epage><pages>23522-23522</pages><artnum>23522</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>This meta-analysis included eligible randomized controlled trials (RCTs) with the aim of determining whether probiotic supplementation can improve
H. pylori
eradication rates. PUBMED, EBSCO, Web of Science and Ovid databases were searched. We included RCTs that investigated the effect of combining probiotics, with or without a placebo, with standard therapy. A total of 21 RCTs that reported standard therapy plus probiotics were included. Compared to the placebo group, the probiotics group was 1.21(OR 1.21, 95% CI: 0.86, 1.69) and 1.28 (OR 1.28, 95% CI: 0.88, 1.86) times more likely to achieve eradication of
H. pylori
infection in intent-to-treat (ITT) analysis and per protocol (PP) analysis, respectively. Probiotics with triple therapy plus a 14-day course of treatment did not improve the eradication of
H. pylori
infection (OR 1.44, 95% CI: 0.87, 2.39) compared to the placebo. Moreover, the placebo plus standard therapy did not improve eradication rates compared to standard therapy alone (
P
= 0.816). However, probiotics did improve the adverse effects of diarrhea and nausea. These pooled data suggest that the use of probiotics plus standard therapy does not improve the eradication rate of
H. pylori
infection compared to the placebo.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26997149</pmid><doi>10.1038/srep23522</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4020/1503/1828/1500 692/699/1503/1828 Adult Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - therapeutic use Diarrhea Dietary Supplements Eradication Female Health risk assessment Helicobacter Infections - diet therapy Helicobacter pylori - pathogenicity Humanities and Social Sciences Humans Infections Male Meta-analysis Middle Aged multidisciplinary Nausea Placebo Effect Placebos Probiotics Probiotics - adverse effects Probiotics - therapeutic use Randomized Controlled Trials as Topic Science Side effects Supplements Treatment Outcome |
| title | Probiotic supplementation does not improve eradication rate of Helicobacter pylori infection compared to placebo based on standard therapy: a meta-analysis |
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