Xanthine oxidoreductase in cancer: more than a differentiation marker

Human xanthine oxidoreductase (XOR) catalyzes the last two steps of purine catabolism and is present in two interconvertible forms, which may utilize O2 or NAD+ as electron acceptors. In addition to uric acid, XOR products may comprise reactive oxygen and nitrogen species that have many biologic eff...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2016-03, Vol.5 (3), p.546-557
Hauptverfasser:	Battelli, Maria Giulia, Polito, Letizia, Bortolotti, Massimo, Bolognesi, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Biosynthesis Breast Cancer Cancer Biology Carcinogens Cell growth Cytotoxicity Dehydrogenases Differentiation Enzymes Gastrointestinal tract Gene Expression Regulation, Neoplastic Hazardous materials Humans Inflammation Liver cancer Mammals Metabolic activation Metabolic rate Metabolism Metabolites Mutagenesis NAD Neoplasia Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Nitrogen oncogenesis Oxidation Prognosis Proteins Reactive nitrogen species Reactive Nitrogen Species - metabolism reactive oxygen and nitrogen species Reactive oxygen species Reactive Oxygen Species - metabolism Review Rodents Transcription Tumorigenesis Tumors Uric acid Uric Acid - metabolism Xanthine Dehydrogenase - genetics Xanthine Dehydrogenase - metabolism Xanthine oxidoreductase
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