A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children

AIMS Low rifampicin plasma concentrations can lead to treatment failure and increased risk of developing drug resistant tuberculosis. The objectives of this study were to characterize the population pharmacokinetics (popPK) of rifampicin in Malawian children and adults with tuberculosis, simulate ex...

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Veröffentlicht in:	British journal of clinical pharmacology 2016-04, Vol.81 (4), p.679-687
Hauptverfasser:	Schipani, Alessandro, Pertinez, Henry, Mlota, Rachel, Molyneux, Elizabeth, Lopez, Nuria, Dzinjalamala, Fraction K., Oosterhout, Joep J., Ward, Steve A., Khoo, Saye, Davies, Gerry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Factors Aged Antitubercular Agents - administration & dosage Antitubercular Agents - blood Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Area Under Curve Biological Availability Child Child, Preschool children Dose-Response Relationship, Drug dosing bands Humans Infant Malawi Middle Aged Models, Biological nonmem Pharmacokinetics population PK Rifampin - administration & dosage Rifampin - blood Rifampin - pharmacokinetics Rifampin - therapeutic use tuberculosis Tuberculosis - blood Tuberculosis - drug therapy Young Adult
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