Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa

Nutritional cues differentially influence the activities of the three quorum sensing (QS) circuits—Las, Rhl, and Pqs—in the pathogen Pseudomonas aeruginosa. A full understanding of how these systems work together to tune virulence factor production to the environment is lacking. Here, we used chemic...

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Veröffentlicht in:	Cell chemical biology 2016-03, Vol.23 (3), p.361-369
Hauptverfasser:	Welsh, Michael A., Blackwell, Helen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Structure Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - pathogenicity Quorum Sensing - drug effects Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Virulence Factors - antagonists & inhibitors Virulence Factors - biosynthesis
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