Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current stra...
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| Veröffentlicht in: | Stem cells translational medicine 2016-04, Vol.5 (4), p.530-538 |
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| creator | Chong, Mark Seow Khoon Ng, Wei Kai Chan, Jerry Kok Yen |
| description | Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the vasculogenic, angiogenic, and beneficial paracrine effects of transplanted EPCs in the treatment of ischemic diseases. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The present study provides a concise summary of the different EPC populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Significance
Endothelial progenitor cells (EPCs) have immense clinical value for cardiovascular therapies. The present study provides a concise description of the EPC subpopulations being evaluated for clinical applications. The current major lines of investigation involving preclinical and clinical evaluations of EPCs are discussed, and significant gaps limiting the translation of EPCs are highlighted. The present report could be useful for clinicians and clinical researchers with interests in ischemic therapy and for basic scientists working in the related fields of tissue engineering and regenerative medicine. |
| doi_str_mv | 10.5966/sctm.2015-0227 |
| format | Article |
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Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the vasculogenic, angiogenic, and beneficial paracrine effects of transplanted EPCs in the treatment of ischemic diseases. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The present study provides a concise summary of the different EPC populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Significance
Endothelial progenitor cells (EPCs) have immense clinical value for cardiovascular therapies. The present study provides a concise description of the EPC subpopulations being evaluated for clinical applications. The current major lines of investigation involving preclinical and clinical evaluations of EPCs are discussed, and significant gaps limiting the translation of EPCs are highlighted. The present report could be useful for clinicians and clinical researchers with interests in ischemic therapy and for basic scientists working in the related fields of tissue engineering and regenerative medicine.</description><identifier>ISSN: 2157-6564</identifier><identifier>EISSN: 2157-6580</identifier><identifier>DOI: 10.5966/sctm.2015-0227</identifier><identifier>PMID: 26956207</identifier><language>eng</language><publisher>Durham, NC, USA: AlphaMed Press</publisher><subject>Angiogenesis ; Animals ; Biomarkers ; Cardiovascular disease ; Clinical translation ; Endothelial cell ; Endothelial Progenitor Cells - physiology ; Endothelial Progenitor Cells - transplantation ; Hematopoietic cells ; Hematopoietic progenitors ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic Stem Cells - physiology ; Humans ; Ischemia ; Medical research ; Medicine ; Neovascularization, Physiologic - physiology ; Ontology ; Progenitor cells ; Regenerative medicine ; Regenerative Medicine - methods ; Senescence ; Stem Cell Transplantation - trends ; Stem cells ; Stem/progenitor cell ; Tissue engineering ; Tissue Engineering and Regenerative Medicine ; Tissue regeneration ; Tissue-specific stem cells ; Vascular endothelial growth factor</subject><ispartof>Stem cells translational medicine, 2016-04, Vol.5 (4), p.530-538</ispartof><rights>2016 AlphaMed Press</rights><rights>AlphaMed Press.</rights><rights>2016. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>AlphaMed Press 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5340-8839ca8b3ead7c43a10068839a472eedc8b2f4c1ccc2b7c5bbb1526d70d469813</citedby><cites>FETCH-LOGICAL-c5340-8839ca8b3ead7c43a10068839a472eedc8b2f4c1ccc2b7c5bbb1526d70d469813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798740/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798740/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11561,27923,27924,45573,45574,46051,46475,53790,53792</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.5966%2Fsctm.2015-0227$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26956207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chong, Mark Seow Khoon</creatorcontrib><creatorcontrib>Ng, Wei Kai</creatorcontrib><creatorcontrib>Chan, Jerry Kok Yen</creatorcontrib><title>Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges</title><title>Stem cells translational medicine</title><addtitle>Stem Cells Transl Med</addtitle><description>Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the vasculogenic, angiogenic, and beneficial paracrine effects of transplanted EPCs in the treatment of ischemic diseases. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The present study provides a concise summary of the different EPC populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Significance
Endothelial progenitor cells (EPCs) have immense clinical value for cardiovascular therapies. The present study provides a concise description of the EPC subpopulations being evaluated for clinical applications. The current major lines of investigation involving preclinical and clinical evaluations of EPCs are discussed, and significant gaps limiting the translation of EPCs are highlighted. 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Widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the vasculogenic, angiogenic, and beneficial paracrine effects of transplanted EPCs in the treatment of ischemic diseases. Despite these promising results, widespread clinical acceptance of EPCs for clinical therapies remains hampered by several challenges. The present study provides a concise summary of the different EPC populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. The challenges and issues surrounding the use of EPCs and the current strategies being developed to improve the harvest efficiency and functionality of EPCs for application in regenerative medicine are discussed.
Significance
Endothelial progenitor cells (EPCs) have immense clinical value for cardiovascular therapies. The present study provides a concise description of the EPC subpopulations being evaluated for clinical applications. The current major lines of investigation involving preclinical and clinical evaluations of EPCs are discussed, and significant gaps limiting the translation of EPCs are highlighted. The present report could be useful for clinicians and clinical researchers with interests in ischemic therapy and for basic scientists working in the related fields of tissue engineering and regenerative medicine.</abstract><cop>Durham, NC, USA</cop><pub>AlphaMed Press</pub><pmid>26956207</pmid><doi>10.5966/sctm.2015-0227</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Animals Biomarkers Cardiovascular disease Clinical translation Endothelial cell Endothelial Progenitor Cells - physiology Endothelial Progenitor Cells - transplantation Hematopoietic cells Hematopoietic progenitors Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - physiology Humans Ischemia Medical research Medicine Neovascularization, Physiologic - physiology Ontology Progenitor cells Regenerative medicine Regenerative Medicine - methods Senescence Stem Cell Transplantation - trends Stem cells Stem/progenitor cell Tissue engineering Tissue Engineering and Regenerative Medicine Tissue regeneration Tissue-specific stem cells Vascular endothelial growth factor |
| title | Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges |
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