Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
Peripartum cardiomyopathy shares clinical features with idiopathic dilated cardiomyopathy, a disorder associated with mutations in more than 40 genes. This study shows that mutations in some of these genes, notably TTN, also have a strong association with this condition. Peripartum cardiomyopathy is...
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| Veröffentlicht in: | The New England journal of medicine 2016-01, Vol.374 (3), p.233-241 |
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| creator | Ware, James S Li, Jian Mazaika, Erica Yasso, Christopher M DeSouza, Tiffany Cappola, Thomas P Tsai, Emily J Hilfiker-Kleiner, Denise Kamiya, Chizuko A Mazzarotto, Francesco Cook, Stuart A Halder, Indrani Prasad, Sanjay K Pisarcik, Jessica Hanley-Yanez, Karen Alharethi, Rami Damp, Julie Hsich, Eileen Elkayam, Uri Sheppard, Richard Kealey, Angela Alexis, Jeffrey Ramani, Gautam Safirstein, Jordan Boehmer, John Pauly, Daniel F Wittstein, Ilan S Thohan, Vinay Zucker, Mark J Liu, Peter Gorcsan, John McNamara, Dennis M Seidman, Christine E Seidman, Jonathan G Arany, Zoltan |
| description | Peripartum cardiomyopathy shares clinical features with idiopathic dilated cardiomyopathy, a disorder associated with mutations in more than 40 genes. This study shows that mutations in some of these genes, notably
TTN,
also have a strong association with this condition.
Peripartum cardiomyopathy is marked by the development of maternal systolic heart failure late in pregnancy or early in the postpartum period.
1
,
2
The incidence varies from 1 in 100 to 1 in 300 in geographic hot spots, including Nigeria and Haiti, to 1 in 1000 to 1 in 4000 in Europe and the United States. The strongest known risk factors are the presence of preeclampsia, twin gestation, and advanced maternal age. Among patients with peripartum cardiomyopathy, heart failure can resolve but often does not: rates of death of 5 to 10% are common, and 4% of cardiac transplantations in the . . . |
| doi_str_mv | 10.1056/NEJMoa1505517 |
| format | Article |
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TTN,
also have a strong association with this condition.
Peripartum cardiomyopathy is marked by the development of maternal systolic heart failure late in pregnancy or early in the postpartum period.
1
,
2
The incidence varies from 1 in 100 to 1 in 300 in geographic hot spots, including Nigeria and Haiti, to 1 in 1000 to 1 in 4000 in Europe and the United States. The strongest known risk factors are the presence of preeclampsia, twin gestation, and advanced maternal age. Among patients with peripartum cardiomyopathy, heart failure can resolve but often does not: rates of death of 5 to 10% are common, and 4% of cardiac transplantations in the . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1505517</identifier><identifier>PMID: 26735901</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Cardiomyopathies - genetics ; Cardiomyopathy ; Cardiomyopathy, Dilated - genetics ; Case-Control Studies ; Connectin ; Connectin - chemistry ; Connectin - genetics ; Dilated cardiomyopathy ; Female ; Genes ; Genetic Predisposition to Disease ; Heart ; Humans ; Mutation ; Peripartum Period ; Pregnancy ; Pregnancy Complications, Cardiovascular - genetics ; Protein Isoforms ; Proteins ; Sequence Analysis, DNA ; Splicing ; Stroke Volume</subject><ispartof>The New England journal of medicine, 2016-01, Vol.374 (3), p.233-241</ispartof><rights>Copyright © 2016 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-f0ce7877c1d0e73696be49642afcbd115c6e5b625a6c87a525ed9ad47ed191433</citedby><cites>FETCH-LOGICAL-c555t-f0ce7877c1d0e73696be49642afcbd115c6e5b625a6c87a525ed9ad47ed191433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1505517$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1505517$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26735901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ware, James S</creatorcontrib><creatorcontrib>Li, Jian</creatorcontrib><creatorcontrib>Mazaika, Erica</creatorcontrib><creatorcontrib>Yasso, Christopher M</creatorcontrib><creatorcontrib>DeSouza, Tiffany</creatorcontrib><creatorcontrib>Cappola, Thomas P</creatorcontrib><creatorcontrib>Tsai, Emily J</creatorcontrib><creatorcontrib>Hilfiker-Kleiner, Denise</creatorcontrib><creatorcontrib>Kamiya, Chizuko A</creatorcontrib><creatorcontrib>Mazzarotto, Francesco</creatorcontrib><creatorcontrib>Cook, Stuart A</creatorcontrib><creatorcontrib>Halder, Indrani</creatorcontrib><creatorcontrib>Prasad, Sanjay K</creatorcontrib><creatorcontrib>Pisarcik, Jessica</creatorcontrib><creatorcontrib>Hanley-Yanez, Karen</creatorcontrib><creatorcontrib>Alharethi, Rami</creatorcontrib><creatorcontrib>Damp, Julie</creatorcontrib><creatorcontrib>Hsich, Eileen</creatorcontrib><creatorcontrib>Elkayam, Uri</creatorcontrib><creatorcontrib>Sheppard, Richard</creatorcontrib><creatorcontrib>Kealey, Angela</creatorcontrib><creatorcontrib>Alexis, Jeffrey</creatorcontrib><creatorcontrib>Ramani, Gautam</creatorcontrib><creatorcontrib>Safirstein, Jordan</creatorcontrib><creatorcontrib>Boehmer, John</creatorcontrib><creatorcontrib>Pauly, Daniel F</creatorcontrib><creatorcontrib>Wittstein, Ilan S</creatorcontrib><creatorcontrib>Thohan, Vinay</creatorcontrib><creatorcontrib>Zucker, Mark J</creatorcontrib><creatorcontrib>Liu, Peter</creatorcontrib><creatorcontrib>Gorcsan, John</creatorcontrib><creatorcontrib>McNamara, Dennis M</creatorcontrib><creatorcontrib>Seidman, Christine E</creatorcontrib><creatorcontrib>Seidman, Jonathan G</creatorcontrib><creatorcontrib>Arany, Zoltan</creatorcontrib><creatorcontrib>IMAC-2 and IPAC Investigators</creatorcontrib><title>Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Peripartum cardiomyopathy shares clinical features with idiopathic dilated cardiomyopathy, a disorder associated with mutations in more than 40 genes. This study shows that mutations in some of these genes, notably
TTN,
also have a strong association with this condition.
Peripartum cardiomyopathy is marked by the development of maternal systolic heart failure late in pregnancy or early in the postpartum period.
1
,
2
The incidence varies from 1 in 100 to 1 in 300 in geographic hot spots, including Nigeria and Haiti, to 1 in 1000 to 1 in 4000 in Europe and the United States. The strongest known risk factors are the presence of preeclampsia, twin gestation, and advanced maternal age. Among patients with peripartum cardiomyopathy, heart failure can resolve but often does not: rates of death of 5 to 10% are common, and 4% of cardiac transplantations in the . . .</description><subject>Adult</subject><subject>Cardiomyopathies - genetics</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - genetics</subject><subject>Case-Control Studies</subject><subject>Connectin</subject><subject>Connectin - chemistry</subject><subject>Connectin - genetics</subject><subject>Dilated cardiomyopathy</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Mutation</subject><subject>Peripartum Period</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - genetics</subject><subject>Protein Isoforms</subject><subject>Proteins</subject><subject>Sequence Analysis, DNA</subject><subject>Splicing</subject><subject>Stroke 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This study shows that mutations in some of these genes, notably
TTN,
also have a strong association with this condition.
Peripartum cardiomyopathy is marked by the development of maternal systolic heart failure late in pregnancy or early in the postpartum period.
1
,
2
The incidence varies from 1 in 100 to 1 in 300 in geographic hot spots, including Nigeria and Haiti, to 1 in 1000 to 1 in 4000 in Europe and the United States. The strongest known risk factors are the presence of preeclampsia, twin gestation, and advanced maternal age. Among patients with peripartum cardiomyopathy, heart failure can resolve but often does not: rates of death of 5 to 10% are common, and 4% of cardiac transplantations in the . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>26735901</pmid><doi>10.1056/NEJMoa1505517</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2016-01, Vol.374 (3), p.233-241 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4797319 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Cardiomyopathies - genetics Cardiomyopathy Cardiomyopathy, Dilated - genetics Case-Control Studies Connectin Connectin - chemistry Connectin - genetics Dilated cardiomyopathy Female Genes Genetic Predisposition to Disease Heart Humans Mutation Peripartum Period Pregnancy Pregnancy Complications, Cardiovascular - genetics Protein Isoforms Proteins Sequence Analysis, DNA Splicing Stroke Volume |
| title | Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies |
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