Altered Na/Ca exchange distribution in ventricular myocytes from failing hearts

In mammalian cardiac ventricular myocytes, Ca efflux via Na/Ca exchange (NCX) occurs predominantly at T tubules. Heart failure is associated with disrupted t-tubular structure, but its effect on t-tubular function is less clear. We therefore investigated t-tubular NCX activity in ventricular myocyte...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2016-01, Vol.310 (2), p.H262-H268
Hauptverfasser:	Gadeberg, Hanne C, Bryant, Simon M, James, Andrew F, Orchard, Clive H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium Signaling Cardiac Excitation and Contraction Cardiomyocytes Cell Separation Coronary Vessels - metabolism Heart failure Heart Failure - metabolism Heart Ventricles - metabolism In Vitro Techniques Ligation Male Myocytes, Cardiac - metabolism Patch-Clamp Techniques Rats Rats, Wistar Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Rodents Sarcoplasmic Reticulum - metabolism Sodium-Calcium Exchanger - metabolism
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