Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats

Inflammation contributes to ANG II-associated impairment of renal autoregulation and microvascular P2X1 receptor signaling, but its role in renal autoregulation in mineralocorticoid-induced hypertension is unknown. Autoregulatory behavior was assessed using the blood-perfused juxtamedullary nephron...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2016-03, Vol.310 (6), p.F456-F465
Hauptverfasser:	Guan, Zhengrong, Singletary, Sean T, Cha, Haword, Van Beusecum, Justin P, Cook, Anthony K, Pollock, Jennifer S, Pollock, David M, Inscho, Edward W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterioles - drug effects Arterioles - metabolism Blood Pressure Chemokine CCL2 - urine Disease Models, Animal Homeostasis - drug effects Hydralazine - pharmacology Hydralazine - therapeutic use Hydrochlorothiazide - pharmacology Hydrochlorothiazide - therapeutic use Hypertension - drug therapy Hypertension - etiology Hypertension - metabolism Hypertension - physiopathology In Vitro Techniques Kidney - blood supply Kidney - drug effects Kidney - metabolism Male Pentosan Sulfuric Polyester - pharmacology Pentosan Sulfuric Polyester - therapeutic use Proteinuria - drug therapy Rats, Sprague-Dawley Receptors, Purinergic P2X1 - metabolism Reserpine - pharmacology Reserpine - therapeutic use Vasoconstriction
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