Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers

Morphologically heterogeneous prostate cancers that behave clinically like small-cell prostate cancers (SCPC) share their chemotherapy responsiveness. We asked whether these clinically defined, morphologically diverse, "aggressive variant prostate cancer (AVPC)" also share molecular featur...

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Veröffentlicht in:	Clinical cancer research 2016-03, Vol.22 (6), p.1520-1530
Hauptverfasser:	Aparicio, Ana M, Shen, Li, Tapia, Elsa Li Ning, Lu, Jing-Fang, Chen, Hsiang-Chun, Zhang, Jiexin, Wu, Guanglin, Wang, Xuemei, Troncoso, Patricia, Corn, Paul, Thompson, Timothy C, Broom, Bradley, Baggerly, Keith, Maity, Sankar N, Logothetis, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor Biopsy Cluster Analysis Disease Progression DNA Copy Number Variations Gene Expression Profiling Humans Immunohistochemistry Male Mutation Neoplasm Staging Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - therapy Receptors, Androgen - genetics Receptors, Androgen - metabolism Signal Transduction Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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