Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

Key Points Approximately 80% of HIV-1 heterosexual transmission events are established from a single transmitted/founder (T/F) virus. During transmission, multiple bottlenecks reduce the viral population from the large, genetically variable population in the blood of a chronically infected donor to...

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Veröffentlicht in:	Nature reviews. Microbiology 2015-07, Vol.13 (7), p.414-425
Hauptverfasser:	Joseph, Sarah B., Swanstrom, Ronald, Kashuba, Angela D. M., Cohen, Myron S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/596/1787 631/326/596/2553 631/326/596/2555 631/326/596/2557 AIDS (Disease) Analysis CD4-Positive T-Lymphocytes - virology Disease transmission Distribution Evolution, Molecular Glycosylation HIV (Viruses) HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus 1 Humans Infectious Diseases Life Sciences Medical Microbiology Microbiological research Microbiology Parasitology Prevention review-article Selection, Genetic Viral Proteins - metabolism Virology
Online-Zugang:	Volltext
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