miR-33-5p, a novel mechano-sensitive microRNA promotes osteoblast differentiation by targeting Hmga2

MicroRNAs (miRNAs) interfere with the translation of specific target mRNAs and are thought to thereby regulate many cellular processes. However, the role of miRNAs in osteoblast mechanotransduction remains to be defined. In this study, we investigated the ability of a miRNA to respond to different m...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23170-23170, Article 23170
Hauptverfasser:	Wang, Han, Sun, Zhongyang, Wang, Yixuan, Hu, Zebing, Zhou, Hua, Zhang, Lianchang, Hong, Bo, Zhang, Shu, Cao, Xinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 14 14/19 3' Untranslated Regions 38 38/77 38/89 631/337/384/331 631/80/304 82 82/80 Animals Base Sequence Binding Sites Bioinformatics Bone loss Cell Differentiation Cell Line Chromosome 5 Fluid flow Gene Expression HMGA2 Protein - genetics HMGA2 Protein - metabolism Humanities and Social Sciences Mechanical stimuli Mechanotransduction Mechanotransduction, Cellular Mice Microgravity MicroRNAs - physiology miRNA multidisciplinary Osteoblastogenesis Osteoblasts Osteoblasts - physiology Plasma RNA Interference Science Shear stress Weightlessness Simulation
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