Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

Prostate cancer (PCa) is the leading malignancy among men. Importantly, this disease is mostly diagnosed at early stages offering a unique chemoprevention opportunity. Therefore, there is an urgent need to identify and target signaling molecules with higher expression/activity in prostate tumors and...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23135-23135, Article 23135
Hauptverfasser:	Deep, Gagan, Kumar, Rahul, Jain, Anil K., Dhar, Deepanshi, Panigrahi, Gati K., Hussain, Anowar, Agarwal, Chapla, El-Elimat, Tamam, Sica, Vincent P., Oberlies, Nicholas H., Agarwal, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/95 38/39 631/67/2195 631/67/327 631/67/589/466 692/4028/67/589/466 Adenocarcinoma - drug therapy Adenocarcinoma - enzymology Animals Annonaceae - chemistry Antineoplastic Agents, Phytogenic - pharmacology Cell Hypoxia Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects CYBB protein Cytotoxicity Humanities and Social Sciences Humans Hypoxia Male Malignancy Membrane Glycoproteins - metabolism Mice, Transgenic multidisciplinary NAD(P)H oxidase NADH, NADPH Oxidoreductases - metabolism NADPH Oxidase 1 NADPH Oxidase 2 NADPH Oxidases - metabolism Plant Extracts - pharmacology Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Science Science (multidisciplinary) Tumors
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