Overexpression of Tbx20 in Adult Cardiomyocytes Promotes Proliferation and Improves Cardiac Function After Myocardial Infarction

BACKGROUND—Adult mammalian cardiomyocytes (CMs) have the potential to proliferate, but this is not sufficient to generate adequate CMs after myocardial infarction (MI). The transcription factor Tbx20 is required for CM proliferation during development and adult CM homeostasis. The ability of Tbx20 o...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2016-03, Vol.133 (11), p.1081-1092
Hauptverfasser:	Xiang, Fu-li, Guo, Minzhe, Yutzey, Katherine E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - genetics Cell Division Cell Size - drug effects Electrocardiography Female Fetal Proteins - biosynthesis Fetal Proteins - genetics Gene Expression Regulation - drug effects Genes, cdc - drug effects Genes, Reporter Heart - physiopathology Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics Immediate-Early Proteins - physiology Mice Mice, Transgenic Muscle Proteins - biosynthesis Muscle Proteins - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Organ Size - drug effects Random Allocation RNA Interference RNA, Messenger - biosynthesis RNA, Messenger - genetics RNA, Small Interfering - genetics Signal Transduction - drug effects Single-Blind Method T-Box Domain Proteins - biosynthesis T-Box Domain Proteins - genetics T-Box Domain Proteins - physiology Tamoxifen - pharmacology Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology
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