mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells

mTOR is a critical target for controlling cell cycle progression, senescence and cell death in mammalian cancer cells. Here we studied the role of mTOR-dependent autophagy in implementating the antiprolifrative effect of mTORC1-specific inhibitor rapamycin and ATP-competitive mTOR kinase inhibitor p...

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Veröffentlicht in:	Oncotarget 2015-12, Vol.6 (42), p.44905-44926
Hauptverfasser:	Gordeev, Serguei A, Bykova, Tatiana V, Zubova, Svetlana G, Bystrova, Olga A, Martynova, Marina G, Pospelov, Valery A, Pospelova, Tatiana V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1A Proteins - genetics Adenovirus E1A Proteins - metabolism Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Cell Cycle Checkpoints - drug effects Cell Cycle Proteins - metabolism Cell Line, Transformed Cell Proliferation - drug effects DNA Fragmentation - drug effects Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - ultrastructure Humans Indoles - pharmacology Mitochondria - drug effects Mitochondria - enzymology Mitochondria - ultrastructure Mitochondrial Degradation - drug effects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Purines - pharmacology Rats Research Paper Signal Transduction - drug effects Sirolimus - pharmacology Time Factors TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Transfection
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