PPARα induces cell apoptosis by destructing Bcl2

PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family, which plays a critical role in inhibiting cell proliferation and tumorigenesis, while the molecular mechanism is still unclear. Here we report that PPARα serves as an E3 ubiquitin ligase to govern Bcl2 protein stability...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncotarget 2015-12, Vol.6 (42), p.44635-44642
Hauptverfasser:	Gao, Jiaming, Liu, Qian, Xu, Ying, Gong, Xin, Zhang, Runyun, Zhou, Chenglin, Su, Zhaoliang, Jin, Jianhua, Shi, Haifeng, Shi, Juanjuan, Hou, Yongzhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis - drug effects Dose-Response Relationship, Drug Gene Expression Regulation, Neoplastic HCT116 Cells HEK293 Cells HeLa Cells Humans Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology PPAR alpha - genetics PPAR alpha - metabolism Proteasome Endopeptidase Complex - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Stability Proteolysis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Research Paper RNA Interference Signal Transduction Time Factors Transfection Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!