Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

Gene therapy for cystic fibrosis using non-viral, plasmid-based formulations has been the subject of intensive research for over two decades but a clinically viable product has yet to materialise in large part due to inefficient transgene expression. Minicircle DNA give enhanced and more persistent...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23125-23125, Article 23125
Hauptverfasser:	Munye, Mustafa M., Tagalakis, Aristides D., Barnes, Josephine L., Brown, Rachel E., McAnulty, Robin J., Howe, Steven J., Hart, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 631/61/201 631/61/391 Animals Axonemal Dyneins - genetics Axonemal Dyneins - metabolism Cell Line Clinical trials Cystic fibrosis Cytokines - metabolism Deoxyribonucleic acid DNA DNA, Circular - genetics Epithelial cells Epithelial Cells - metabolism Female Gene Expression Gene therapy Gene Transfer Techniques Genetic Vectors Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humanities and Social Sciences Humans Inflammation Luciferases, Firefly - genetics Luciferases, Firefly - metabolism Lung - metabolism Lungs Mice multidisciplinary Plasmids Respiratory tract Rodents Science Transfection Transgenes
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