Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model

Human rhinovirus (HRV) is the most common viral infectious agent in humans and is the predominant cause of the common cold. There is a need for appropriate vaccines or therapeutic agents to treat HRV infection. In this study, we investigated whether itraconazole (ICZ) can protect cells from HRV-indu...

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Veröffentlicht in:	Scientific reports 2016-03, Vol.6 (1), p.23110-23110, Article 23110
Hauptverfasser:	Shim, Aeri, Song, Jae-Hyoung, Kwon, Bo-Eun, Lee, Jeong-Jun, Ahn, Jae-Hee, Kim, Yeon-Jeong, Rhee, Ki-Jong, Chang, Sun-Young, Cha, Younggil, Lee, Yong-Soo, Kweon, Mi-Na, Park, Kwi Sung, Kim, Dong-Eun, Cho, Sungchan, Cho, Hyun-Jong, Ko, Hyun-Jeong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 45/77 631/250/255/2514 631/326/596/1296 64/60 Alveoli Animal models Animals Antifungal agents Antiviral activity Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Bronchus Cell Membrane - metabolism Cholesterol Cholesterol - metabolism Common cold Cytokines - metabolism Cytotoxicity Female Humanities and Social Sciences Infections Inflammation Itraconazole Itraconazole - pharmacology Itraconazole - therapeutic use Leukocytes (granulocytic) Lung - virology Membrane trafficking Mice, Inbred BALB C Monocytes multidisciplinary Nuclei Picornaviridae Infections - drug therapy Picornaviridae Infections - prevention & control Picornaviridae Infections - virology Rhinovirus Rhinovirus - drug effects Rhinovirus - physiology Rodents Science Virus Replication
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